ACTH-producing small cell neuroendocrine carcinoma from the gallbladder: a case report and literature review

被引:2
作者
Zhang, Xiaofang [1 ]
Huang, Dihua [1 ]
Pan, Xiaojie [1 ]
Si, Qiya [1 ]
You, Qiaoying [1 ]
机构
[1] Shaoxing Peoples Hosp, Dept Endocrinol, Shaoxing, Zhejiang, Peoples R China
关键词
Cushing syndrome; ectopic adrenocorticotropic hormone syndrome; neuroendocrine tumor; gallbladder; case report; CUSHINGS-SYNDROME; DIAGNOSIS; MANAGEMENT; FEATURES;
D O I
10.3389/fendo.2023.1224381
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Ectopic adrenocorticotropic hormone syndrome (EAS) is a condition of hypercortisolism caused by non-pituitary tumors that secrete adrenocorticotropic hormone (ACTH). A rare occurrence of this syndrome is due to an ACTH-producing neuroendocrine tumor that originates from the gallbladder. One patient with severe hypokalemia and alkalosis was admitted to our hospital. Clinical presentations and radiographic findings confirmed the diagnosis of an aggressive ACTH-producing gallbladder malignancy with multiple liver metastases. The diagnosis was verified by pathological and immunohistochemical measurements from a biopsy of the hepatic metastasis. A literature review identified only four similar cases had been reported. Despite being rare and having a poor prognosis, hormone-producing neuroendocrine tumors that derive from the gallbladder should be considered in the differential diagnosis of ectopic ACTH syndrome.
引用
收藏
页数:6
相关论文
共 13 条
[1]   Consensus on diagnosis and management of Cushing's disease: a guideline update [J].
Fleseriu, Maria ;
Auchus, Richard ;
Bancos, Irina ;
Ben-Shlomo, Anat ;
Bertherat, Jerome ;
Biermasz, Nienke R. ;
Boguszewski, Cesar L. ;
Bronstein, Marcello D. ;
Buchfelder, Michael ;
Carmichael, John D. ;
Casanueva, Felipe F. ;
Castinetti, Frederic ;
Chanson, Philippe ;
Findling, James ;
Gadelha, Monica ;
Geer, Eliza B. ;
Giustina, Andrea ;
Grossman, Ashley ;
Gurnell, Mark ;
Ho, Ken ;
Ioachimescu, Adriana G. ;
Kaiser, Ursula B. ;
Karavitaki, Niki ;
Katznelson, Laurence ;
Kelly, Daniel F. ;
Lacroix, Andre ;
McCormack, Ann ;
Melmed, Shlomo ;
Molitch, Mark ;
Mortini, Pietro ;
Newell-Price, John ;
Nieman, Lynnette ;
Pereira, Alberto M. ;
Petersenn, Stephan ;
Pivonello, Rosario ;
Raff, Hershel ;
Reincke, Martin ;
Salvatori, Roberto ;
Scaroni, Carla ;
Shimon, Ilan ;
Stratakis, Constantine A. ;
Swearingen, Brooke ;
Tabarin, Antoine ;
Takahashi, Yutaka ;
Theodoropoulou, Marily ;
Tsagarakis, Stylianos ;
Valassi, Elena ;
Varlamov, Elena V. ;
Vila, Greisa ;
Wass, John .
LANCET DIABETES & ENDOCRINOLOGY, 2021, 9 (12) :847-875
[2]   DIAGNOSIS AND MANAGEMENT OF ACTH-DEPENDENT CUSHINGS-SYNDROME - COMPARISON OF THE FEATURES IN ECTOPIC AND PITUITARY ACTH PRODUCTION [J].
HOWLETT, TA ;
DRURY, PL ;
PERRY, L ;
DONIACH, I ;
REES, LH ;
BESSER, GM .
CLINICAL ENDOCRINOLOGY, 1986, 24 (06) :699-713
[3]   The ectopic adrenocorticotropin syndrome: Clinical features, diagnosis, management, and long-term follow-up [J].
Isidori, AM ;
Kaltsas, GA ;
Pozza, C ;
Frajese, V ;
Newell-Price, J ;
Reznek, RH ;
Jenkins, PJ ;
Monson, JP ;
Grossman, AB ;
Besser, GM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (02) :371-377
[4]   Ectopic ACTH syndrome [J].
Isidori, Andrea M. ;
Lenzi, Andrea .
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA, 2007, 51 (08) :1217-1225
[5]   The diagnosis and medical management of advanced neuroendocrine tumors [J].
Kaltsas, GA ;
Besser, GM ;
Grossman, AB .
ENDOCRINE REVIEWS, 2004, 25 (03) :458-511
[6]   Neuroendocrine tumor markers [J].
Lamberts, SWJ ;
Hofland, LJ ;
Nobels, FRE .
FRONTIERS IN NEUROENDOCRINOLOGY, 2001, 22 (04) :309-339
[8]   Cushing's syndrome caused by an ACTH-producing large cell neuroendocrine carcinoma of the gallbladder [J].
Lin, Dagmar ;
Suwantarat, Nuntra ;
Kwee, Sandi ;
Miyashiro, Michelle .
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2010, 2 (01) :56-58
[9]   Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Overview of the 2022 WHO Classification of Head and Neck Neuroendocrine Neoplasms [J].
Mete, Ozgur ;
Wenig, Bruce M. .
HEAD & NECK PATHOLOGY, 2022, 16 (01) :123-142
[10]   ACTH-producing cholangiocarcinoma associated with Cushing's syndrome [J].
Papastratis, G ;
Zografos, GN ;
Pappis, HC ;
Kontogeorgos, G ;
Anagnostopoulos, G ;
Kounadi, T ;
Piaditis, G .
ENDOCRINE PATHOLOGY, 1999, 10 (03) :259-263