Asymmetric tandem conjugate addition and reaction with carbocations on acylimidazole Michael acceptors

被引：2

作者：

Mudrakova, Brigita ^{[1
]}

de Figueiredo, Renata Marcia ^{[2
]}

Campagne, Jean-Marc ^{[2
]}

Sebesta, Radovan ^{[1
]}

机构：

[1] Comenius Univ, Fac Nat Sci, Dept Organ Chem, Ilkovicova 6, Bratislava 84215, Slovakia

[2] Univ Montpellier, ICGM, CNRS, ENSCM, Montpellier, France

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 19卷

关键词：

acylimidazole; asymmetric catalysis; carbocation; conjugate addition; enolate; ORGANOMETALLIC REAGENTS; DIMETHYLZINC;

D O I：

10.3762/bjoc.19.65

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We present here a stereoselective tandem reaction based on the asymmetric conjugate addition of dialkylzinc reagents to unsaturated acylimidazoles followed by trapping of the intermediate zinc enolate with carbocations. The use of a chiral NHC ligand provides chiral zinc enolates in high enantiomeric purities. These enolates are reacted with highly electrophilic onium compounds to afford densely substituted acylimidazoles. DFT calculations helped to understand the reactivity of the zinc enolates derived from acylimidazoles and allowed their comparison with metal enolates obtained by other conjugate addition reactions.

引用

页码：881 / 888

页数：8

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