Organ-on-chip models for infectious disease research

被引：30

作者：

Alonso-Roman, Raquel ^{[1
,2
]}

Mosig, Alexander S. ^{[2
,3
,4
]}

Figge, Marc Thilo ^{[2
,5
,6
]}

Papenfort, Kai ^{[2
,6
]}

Eggeling, Christian ^{[2
,7
,8
,9
]}

Schacher, Felix H. ^{[2
,9
,10
]}

Hube, Bernhard ^{[1
,2
,6
]}

Gresnigt, Mark S. ^{[2
,11
]}

机构：

[1] Leibniz Inst Nat Prod Res & Infect Biol, Hans Knoll Inst Leibniz HKI, Dept Microbial Pathogen Mech, Jena, Germany

[2] Friedrich Schiller Univ Jena, Cluster Excellence Balance Microverse, Jena, Germany

[3] Jena Univ Hosp, Inst Biochem 2, Jena, Germany

[4] Friedrich Schiller Univ, Jena Univ Hosp, Ctr Sepsis Control & Care, Jena, Germany

[5] Leibniz HKI, Appl Syst Biol Grp, Jena, Germany

[6] Friedrich Schiller Univ, Fac Biol Sci, Inst Microbiol, Jena, Germany

[7] Leibniz Ctr Photon Infect Res eV, Leibniz Inst Photon Technol, Jena, Germany

[8] Friedrich Schiller Univ Jena, Inst Appl Opt & Biophys, Jena, Germany

[9] Jena Ctr Soft Matter, Jena, Germany

[10] Friedrich Schiller Univ, Inst Organ Chem & Macromol Chem, Jena, Germany

[11] Leibniz HKI, Jr Res Grp Adapt Pathogen Strategies, Jena, Germany

来源：

NATURE MICROBIOLOGY | 2024年 / 9卷 / 04期

基金：

欧盟地平线“2020”;

关键词：

CELLS; GUT; SYSTEMS; MOUSE;

D O I：

10.1038/s41564-024-01645-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Research on microbial pathogens has traditionally relied on animal and cell culture models to mimic infection processes in the host. Over recent years, developments in microfluidics and bioengineering have led to organ-on-chip (OoC) technologies. These microfluidic systems create conditions that are more physiologically relevant and can be considered humanized in vitro models. Here we review various OoC models and how they have been applied for infectious disease research. We outline the properties that make them valuable tools in microbiology, such as dynamic microenvironments, vascularization, near-physiological tissue constitutions and partial integration of functional immune cells, as well as their limitations. Finally, we discuss the prospects for OoCs and their potential role in future infectious disease research. This Review discusses how organ-on-chip models can applied for infectious disease research.

引用

页码：891 / 904

页数：14

共 99 条

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