The effects of ghrelin and LEAP-2 in energy homeostasis are modulated by thermoneutrality, high-fat diet and aging

被引：6

作者：

Casado, S. ^{[1
,2
]}

Varela-Miguens, M. ^{[1
,2
]}

Diz, T. de Oliveira ^{[2
]}

Quintela-Vilarino, C. ^{[1
,2
]}

Nogueiras, R. ^{[1
,2
,3
]}

Dieguez, C. ^{[1
,2
,3
]}

Tovar, S. ^{[1
,2
,3
]}

机构：

[1] Univ Santiago De Compostela, Dept Fisioloxia, Inst Invest Sanitarias Santiago De Compostela IDIS, Santiago De Compostela 15782, Spain

[2] Univ Santiago De Compostela, Ctr Invest Med Mol CIMUS, Inst Invest Sanitarias Santiago De Compostela IDIS, Santiago De Compostela 15782, Spain

[3] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid 28029, Spain

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2024年 / 47卷 / 08期

关键词：

Ghrelin; LEAP-2; Energy; Obesity; Aging; Adipose tissue; OPTIMAL HOUSING TEMPERATURES; BODY-TEMPERATURE; TREAT OBESITY; BROWN FAT; RECEPTOR; MICE; METABOLISM; ADIPOSITY; NEURONS; LIVER;

D O I：

10.1007/s40618-024-02307-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

PurposeLiver-expressed antimicrobial peptide 2 (LEAP-2) has been recently identified as the endogenous non-competitive allosteric antagonist of the growth hormone secretagogue receptor 1a (GHSR1a). In rodents, LEAP-2 blunts ghrelin-induced feeding and its plasma levels are modulated in response to nutritional status, being decreased upon fasting and increased in high-fat diet (HFD) fed mice. Clinical data support the regulation of circulating LEAP-2 by nutrient availability in humans. In this work, our primary objective was to examine the chronic effects of ghrelin and LEAP-2 administration on food intake, adiposity, and energy expenditure in young mice subjected to standard and HFD at both room temperature and at thermoneutrality. Furthermore, we aimed to assess the impact of these two hormones on aging mice.ResultsOur results indicate that LEAP-2 produces a significant decrease of body weight and adiposity, an increase in energy expenditure, and activation of the thermogenic program in white and brown adipose tissue depots. However, this effect is not maintained under HFD or under thermoneutral conditions and is only partially observed in aging mice.ConclusionIn summary our studies describe the central effects of LEAP-2 within distinct experimental contexts, and contribute to the comprehension of LEAP-2's role in energy metabolism.

引用

页码：2061 / 2074

页数：14