Construction of molecularly imprinted voltammetric sensor based on rGO/Ti3C2Tx for the selective determination of acetaminophen

Acetaminophen (AP) is one of the most commonly used nonsteroidal anti-inflammatory and antipyretic analgesics, but overdose of AP can produce toxic metabolite in the body, eventually leading to liver and kidney damage, which make it necessary to detect and control the proper amount. The sensor harnessed a molecularly imprinted polymer (MIP) for selective recognition of AP, and Ti3C2Tx nanosheets modified by rGO for signal amplification. The electrochemical sensing performance of MIP/rGO/Ti3C2Tx electrode toward AP was investigated. Under optimized conditions, the sensor has low detection limit (LOD = 1.58 nM, S/N = 3), wide detection range (10(-8)-10(-3) M), strong selectivity, and good stability. In addition, the sensor can be applied to the AP detection in simulate real samples, which provides an effective method and a useful way for the application of new 2D nanomaterials in the field of sensing. Graphical abstract