Improved arterial inflammation with high dose omega-3 fatty acids in patients with elevated lipoprotein(a): Selective effect of eicosapentaenoic acid?

被引：4
作者：
Ward, Natalie C.
Ying, Qidi
Chan, Dick C.
Pang, Jing
Mori, Trevor A.
Schultz, Carl J.
Dwivedi, Girish
Francis, Roslyn J.
Watts, Gerald F. [1 ]
机构：
[1] Univ Western Australia, Dobney Hypertens Ctr, Med Sch, Perth, WA, Australia
来源：
JOURNAL OF CLINICAL LIPIDOLOGY | 2023年 / 17卷 / 05期
基金：
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词：
Lipoprotein(a); Atherosclerotic; cardiovascular disease; Fish oils; Arterial inflammation; PET/CT imaging;
D O I：
10.1016/j.jacl.2023.08.004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Elevated lipoprotein(a) [Lp(a)] is a causal risk factor for atherosclerotic cardiovascular disease. However, there are no approved and effective treatments for lowering Lp(a) and the associated cardio-vascular risks. Omega-3 fatty acids (omega-3FAs), primarily eicosapentaenoic acid (EPA) and docosahex-aenoic acid (DHA), have both triglyceride-lowering and anti-inflammatory properties. This pilot study investigated the effect of high dose omega-3FAs (3.6 g/day) on arterial inflammation in 12 patients with elevated Lp(a) (> 0.5 g/L) and stable coronary artery disease (CAD) receiving cholesterol-lowering treatment. Arterial inflammation w as determined using 18F-fluorodexo yglucose positron emission tomography/computed tomography before and after 12-weeks intervention. omega-3FAs significantly lowered plasma
引用
收藏
页码：694 / 699
页数：6
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