Aim: The aim of this study is to evaluate the treatment of chronic diseases, which have a significant place in the course and mortality from COVID-19, taking into account the experience of a tertiary hospital. Material and Methods: The study included a group of 407 patients with chronic disease symptoms who were followed up at the COVID-19 Polyclinic of Malatya Training and Research Hospital between August 1, 2020 and December 31, 2020. The research data were examined by the researcher using archive materials of COVID-19 Polyclinic according to the parameters determined by the researcher. The researcher gathered information about these study sample parameters from patient files and saved it in a Microsoft Office Excel file. Results: In our study, patients with positive PCR test results had 30.9% asthma, 23.6% arrhythmia, 16.4% HT, 10.9% heart failure and 9.1% DM. Among patients with negative PCR results, 20.5% had HT, 17.6% had DM, 16.2% had asthma, 16.2% had arrhythmia and 11% had COPD. Discussion: Based on the results of the study, it can be concluded that there is a significant association between chronic diseases and PCR test results. This suggests that individuals with pre-existing chronic conditions may be more prone to contracting the virus and testing positive for COVID-19.