Risk factors for developing both primary breast and primary ovarian cancer: A systematic review

Objective: Women with breast cancer have an increased risk of primary ovarian cancer (BR & RARR;OV), and women with ovarian cancer have an increased risk of primary breast cancer (OV & RARR;BR). This systematic review summarizes risk factors for developing BR & RARR;OV and OV & RARR;BR.Methods: We searched PubMed and Embase until June 2022.Results: We identified 23 articles meeting our inclusion criteria. Studies observed a lower risk of BR & RARR;OV for Black versus White women, alcohol consumption, radiotherapy and hormone therapy, BRCA2 versus BRCA1, and ER/PR positive versus negative breast tumors, and a higher risk with family history of breast/ovarian cancer, triple negative versus luminal breast cancer, and higher grade breast tumors. There was an increased risk of OV & RARR;BR with family history of cancer.Conclusions: Tumor characteristics, and genetic and familial factors are associated with risk of BR & RARR;OV and OV & RARR;BR. These results could aid clinicians in decision-making for breast and ovarian cancer patients, including risk-reducing strategies.