Nanostructured cubosomal in situ nasal gel for the treatment of migraine

The purpose of this research was to develop a cubosomal in situ nasal gel using a novel mucoadhesive agent and to enhance the availability of sumatriptan succinate in brain with better CNS targeting potential for the efficient treatment of migraine. Glycerol monooleate (GMO) and Poloxamer 407 (P407) were used to prepare cubosomal dispersion. The developed formulation was evaluated for particle size, zeta potential, transmission electron microsopy, entrapment efficiency, drug content, in vitro drug release, ex vivo drug diffusion, histological study and in vivo bio-distribution study. Cubosomal insitu nasal gel was prepared by using sodium alginate (ionactivated polymer) and kolliphor 188 (Temperature sensitive polymer). Samanea saman seed gum was used as a mucoadhesive agent. Optimized cubosomal in situ nasal gel was subjected to in vivo bio-distribution studies in rats. In situ nasal gel showed a significantly higher concentration of sumatriptan succinate in the brain as compared to intravenous solution. Thus, the prepared cubosomal in situ nasal gel could be considered as one of the promising carriers for targeting CNS-acting drugs through the intranasal route.