MiR-30a-5p inhibits cell behaviors in esophageal cancer via modulating CBX2

被引：5
|
作者：
Peng, Luxing [1 ,2 ]
Huang, Xinjun [1 ]
Qing, Defeng [1 ]
Lu, Heming [1 ]
Liu, Xu [1 ]
Chen, Jiaxin [1 ]
Long, Xianfeng [1 ]
Pang, Qiang [1 ]
机构：
[1] Peoples Hosp Guangxi Zhuang Autonomous Reg, Ctr Oncol, Dept Radiotherapy, Nanning 530021, Guangxi Zhuang, Peoples R China
[2] Peoples Hosp Guangxi Zhuang Autonomous Reg, Ctr Oncol, Dept Radiotherapy, 6 Taoyuan, Nanning 530021, Guangxi Zhuang, Peoples R China
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2023年 / 826卷
关键词：
Esophageal cancer; MiR-30a-5p; CBX2; Proliferation; Therapeutic target; TUMOR-SUPPRESSOR; PROLIFERATION; EXPRESSION; CARCINOMA; INVASION; BIOMARKERS; DIAGNOSIS; MICRORNAS; PROGNOSIS; GROWTH;
D O I：
10.1016/j.mrfmmm.2023.111818
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: This investigation studied the impacts of the miR-30a-5p/CBX2 axis on esophageal cancer (EC). Methods: Research objects were ascertained using The Cancer Genome Atlas database. Followed by qRT-PCR, western blot, dual-luciferase reporter, MTT, Transwell, and wound healing approaches, we tested gene expression and varying cell behaviorsResults: Conspicuously miR-30 family members (miR-30a-5p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-30e5p) downregulation and CBX2 upregulation were discovered in EC cells. miR-30 family members target CBX2 and inhibited CBX2 expression. EC cell behaviors were inhibited by miR-30a-5p/CBX2 axis.Conclusion: MiR-30a-5p draws a new inspiration for EC treatment.
引用
收藏
页数：8
相关论文
共 50 条
  • [31] miRNA sequencing analysis of healthy and atretic follicles of chickens revealed that miR-30a-5p inhibits granulosa cell death via targeting Beclin1
    Haorong He
    Dongmei Li
    Yongtong Tian
    Qinyao Wei
    Felix Kwame Amevor
    Congjiao Sun
    Chunlin Yu
    Chaowu Yang
    Huarui Du
    Xiaosong Jiang
    Menggen Ma
    Can Cui
    Zhichao Zhang
    Kai Tian
    Yao Zhang
    Qing Zhu
    Huadong Yin
    Journal of Animal Science and Biotechnology, 13
  • [32] LncRNA DLEU2 accelerates the tumorigenesis and invasion of non-small cell lung cancer by sponging miR-30a-5p
    Wu, Weiming
    Zhao, Yonghong
    Gao, Erji
    Li, Yang
    Guo, Xiang
    Zhao, Tiancheng
    He, Weiwei
    Zhang, Huibiao
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (01) : 441 - 450
  • [33] miR-30a-5p together with miR-210-3p as a promising biomarker for non-small cell lung cancer: A preliminary study
    Switlik, Weronika
    Karbownik, Michal Seweryn
    Suwalski, Michal
    Kozak, Jozef
    Szemraj, Janusz
    CANCER BIOMARKERS, 2018, 21 (02) : 479 - 488
  • [34] CBX2 promotes cervical cancer cell proliferation and resistance to DNA-damaging treatment via maintaining cancer stemness
    Li, Wenhan
    Shi, Ru
    Gao, Yumei
    Wang, Xiaoman
    Shen, Tiantian
    Liu, Xiaoli
    Wu, Qiulei
    Xu, Xiaohan
    Wang, Zanhong
    Du, Shi
    Sun, Si
    Yang, Lu
    Cai, Jing
    Liu, Lin
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2025, 301 (02)
  • [35] Deciphering the Role of miR-30a-5p and DLGAP1 Gene in Non-small Cell Lung Cancer
    Switlik, Weronika
    Wyzewski, Zbigniew
    Gregorczyk-zboroch, Karolina
    Gietler, Marta
    Pudlarz, Agnieszka
    Szewinska, Joanna
    Orzechowski, Slawomir
    Jakiela, Slawomir
    Szemraj, Janusz
    ANTICANCER RESEARCH, 2024, 44 (06) : 2445 - 2451
  • [36] LncRNA XIST Inhibits Gastric Cancer Progression Through the Wnt Pathway by Regulating the miR-30a-5p/SOX9 Axis
    Gao, Wei
    Qu, Fei
    JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2023, 19 (04) : 613 - 623
  • [37] Effects of Wnt/β-Catenin Signal Pathway Regulated by miR-342-5p Targeting CBX2 on Proliferation, Metastasis and Invasion of Ovarian Cancer Cells
    Dou, Yan
    Chen, Fengxia
    Lu, Yawan
    Qiu, Huanhuan
    Zhang, Hongmei
    CANCER MANAGEMENT AND RESEARCH, 2020, 12 : 3783 - 3794
  • [38] MiR-30a-5p promotes cholangiocarcinoma cell proliferation through targeting SOCS3
    Zhang, Jia Wei
    Wang, Xing
    Li, Gao Chao
    Wang, Dong
    Han, Sheng
    Zhang, Yao Dong
    Luo, Chen Huan
    Wang, Hong Wei
    Jiang, Wang Jie
    Li, Chang Xian
    Li, Xiang Cheng
    JOURNAL OF CANCER, 2020, 11 (12): : 3604 - 3614
  • [39] MiR-30a-5p Enhances Cisplatin Sensitivity by Downregulating RIF1 in Ovarian Cancer
    Yao, Wenlei
    Wang, Yongfang
    Huang, Mei
    Zhou, Jianbo
    Zheng, Renshan
    Jin, Cuiping
    Zhang, Yanhua
    ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2023, 53 (03): : 418 - 426
  • [40] Plasma miR-30a-5p as an early novel noninvasive diagnostic and prognostic biomarker for lung cancer
    Liang, Ling-Bo
    Zhu, Wen-Jun
    Chen, Xue-Mei
    Luo, Feng-Ming
    FUTURE ONCOLOGY, 2019, 15 (32) : 3711 - 3721
12345