MiR-30a-5p inhibits cell behaviors in esophageal cancer via modulating CBX2

被引：5
作者：
Peng, Luxing [1 ,2 ]
Huang, Xinjun [1 ]
Qing, Defeng [1 ]
Lu, Heming [1 ]
Liu, Xu [1 ]
Chen, Jiaxin [1 ]
Long, Xianfeng [1 ]
Pang, Qiang [1 ]
机构：
[1] Peoples Hosp Guangxi Zhuang Autonomous Reg, Ctr Oncol, Dept Radiotherapy, Nanning 530021, Guangxi Zhuang, Peoples R China
[2] Peoples Hosp Guangxi Zhuang Autonomous Reg, Ctr Oncol, Dept Radiotherapy, 6 Taoyuan, Nanning 530021, Guangxi Zhuang, Peoples R China
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2023年 / 826卷
关键词：
Esophageal cancer; MiR-30a-5p; CBX2; Proliferation; Therapeutic target; TUMOR-SUPPRESSOR; PROLIFERATION; EXPRESSION; CARCINOMA; INVASION; BIOMARKERS; DIAGNOSIS; MICRORNAS; PROGNOSIS; GROWTH;
D O I：
10.1016/j.mrfmmm.2023.111818
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: This investigation studied the impacts of the miR-30a-5p/CBX2 axis on esophageal cancer (EC). Methods: Research objects were ascertained using The Cancer Genome Atlas database. Followed by qRT-PCR, western blot, dual-luciferase reporter, MTT, Transwell, and wound healing approaches, we tested gene expression and varying cell behaviorsResults: Conspicuously miR-30 family members (miR-30a-5p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-30e5p) downregulation and CBX2 upregulation were discovered in EC cells. miR-30 family members target CBX2 and inhibited CBX2 expression. EC cell behaviors were inhibited by miR-30a-5p/CBX2 axis.Conclusion: MiR-30a-5p draws a new inspiration for EC treatment.
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页数：8
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