MiR-30a-5p inhibits cell behaviors in esophageal cancer via modulating CBX2

被引：5

作者：

Peng, Luxing ^{[1
,2
]}

Huang, Xinjun ^{[1
]}

Qing, Defeng ^{[1
]}

Lu, Heming ^{[1
]}

Liu, Xu ^{[1
]}

Chen, Jiaxin ^{[1
]}

Long, Xianfeng ^{[1
]}

Pang, Qiang ^{[1
]}

机构：

[1] Peoples Hosp Guangxi Zhuang Autonomous Reg, Ctr Oncol, Dept Radiotherapy, Nanning 530021, Guangxi Zhuang, Peoples R China

[2] Peoples Hosp Guangxi Zhuang Autonomous Reg, Ctr Oncol, Dept Radiotherapy, 6 Taoyuan, Nanning 530021, Guangxi Zhuang, Peoples R China

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2023年 / 826卷

关键词：

Esophageal cancer; MiR-30a-5p; CBX2; Proliferation; Therapeutic target; TUMOR-SUPPRESSOR; PROLIFERATION; EXPRESSION; CARCINOMA; INVASION; BIOMARKERS; DIAGNOSIS; MICRORNAS; PROGNOSIS; GROWTH;

D O I：

10.1016/j.mrfmmm.2023.111818

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: This investigation studied the impacts of the miR-30a-5p/CBX2 axis on esophageal cancer (EC). Methods: Research objects were ascertained using The Cancer Genome Atlas database. Followed by qRT-PCR, western blot, dual-luciferase reporter, MTT, Transwell, and wound healing approaches, we tested gene expression and varying cell behaviorsResults: Conspicuously miR-30 family members (miR-30a-5p, miR-30b-5p, miR-30c-5p, miR-30d-5p, miR-30e5p) downregulation and CBX2 upregulation were discovered in EC cells. miR-30 family members target CBX2 and inhibited CBX2 expression. EC cell behaviors were inhibited by miR-30a-5p/CBX2 axis.Conclusion: MiR-30a-5p draws a new inspiration for EC treatment.

引用

页数：8

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