Design, synthesis, and evaluation of 1,2,3-triazole-based benzenesulfonamide and flavonol hybrid molecules as anticancer agents

被引：6

作者：

Chen, Yu-Xun ^{[1
]}

Chang, Chuan-Hsin ^{[2
]}

Li, Cai-Wei ^{[3
]}

Chen, Jih-Jung ^{[4
,5
,6
]}

Shih, Tzenge-Lien ^{[1
,6
]}

机构：

[1] Tamkang Univ, Dept Chem, New Taipei City, Taiwan

[2] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Taoyuan, Taiwan

[3] Natl Yang Ming Chiao Tung Univ, Inst Tradit Med, Taipei, Taiwan

[4] Natl Yang Ming Chiao Tung Univ, Coll Pharmaceut Sci, Dept Pharm, Taipei, Taiwan

[5] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, Taiwan

[6] Tamkang Univ, Dept Chem, New Taipei City 251301, Taiwan

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2023年 / 70卷 / 10期

关键词：

1,2,3-triazole; benzenesulfonamide; click chemistry; flavonol; human non-small-cell lung cancer cells; hybrid molecules; BIOLOGICAL EVALUATION; CLICK CHEMISTRY; DERIVATIVES; SULFONAMIDES;

D O I：

10.1002/jccs.202300279

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Background: The design and synthesis of hybrid molecules will explore finding new drugs.Objectives: The synthesized hybrid molecules to evaluate their biological properties.Methods: Apply click chemistry to tether flavonols and benzenesulfonamide.Results: Two drug candidates show potential against lung cancer.Conclusions: Two drug candidates did not affect the normal cells and provided a new drug design route.

引用

收藏

页码：1924 / 1936

页数：13

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