Long non-coding RNAs: Fundamental regulators and emerging targets of cancer stem cells

被引:17
作者
Shabna, Aboo [1 ,2 ,3 ,4 ]
Bindhya, Sadanandhan [1 ,2 ]
Sidhanth, Chirukandath [1 ,2 ]
Garg, Manoj [5 ]
Ganesan, Trivadi S. [1 ,2 ,3 ]
机构
[1] Canc Inst WIA, Dept Med Oncol, Lab Canc Biol, Chennai 600020, India
[2] Canc Inst WIA, Dept Clin Res, Lab Canc Biol, Chennai 600020, India
[3] Sri Ramachandra Inst Higher Educ & Res, Dept Med Oncol, Lab Canc Biol, Chennai 610016, India
[4] Indian Council Med Res, Natl Inst Nutrt, Dept Endocrinol, Hyderabad 50007, India
[5] Amity Univ Uttar Pradesh, Amity Inst Mol Med & Stem Cell Res, Sect 125, Noida 201301, India
来源
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2023年 / 1878卷 / 03期
关键词
Cancer stem cells; Long non-coding RNAs; Drug resistance; Signaling pathways; COLORECTAL-CANCER; LINCRNA HOTAIR; ROR PROMOTES; RESISTANCE; LNCRNA; PROLIFERATION; EXPRESSION; CHROMATIN; CLASSIFICATION; TRANSCRIPTION;
D O I
10.1016/j.bbcan.2023.188899
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cancer is one of the leading causes of death worldwide, primarily due to the dearth of efficient therapies that result in long-lasting remission. This is especially true in cases of metastatic cancer where drug resistance causes the disease to recur after treatment. One of the factors contributing to drug resistance, metastasis, and aggressiveness of the cancer is cancer stem cells (CSCs) or tumor-initiating cells. As a result, CSCs have emerged as a potential target for drug development. In the present review, we have examined and highlighted the lncRNAs with their regulatory functions specific to CSCs. Moreover, we have discussed the difficulties and various methods involved in identifying lncRNAs that can play a particular role in regulating and maintaining CSCs. Interestingly, this review only focuses on those lncRNAs with strong functional evidence for CSC specificity and the mechanistic role that allows them to be CSC regulators and be the focus of CSC-specific drug development.
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页数:13
相关论文
共 123 条
[1]   Brief Report: The lincRNA Hotair Is Required for Epithelial-to-Mesenchymal Transition and Stemness Maintenance of Cancer Cell Lines [J].
Alves, Cleidson Padua ;
Fonseca, Aline Simoneti ;
Muys, Bruna Rodrigues ;
Bueno, Rafaela de Barros e Lima ;
Buerger, Matheus Carvalho ;
de Souza, Jorge E. S. ;
Valente, Valeria ;
Zago, Marco Antonio ;
Silva, Wilson Araujo, Jr. .
STEM CELLS, 2013, 31 (12) :2827-2832
[2]   Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment [J].
Aponte, Pedro M. ;
Caicedo, Andres .
STEM CELLS INTERNATIONAL, 2017, 2017
[3]   Therapeutic Targeting of Long Non-Coding RNAs in Cancer [J].
Arun, Gayatri ;
Diermeier, Sarah D. ;
Spector, David L. .
TRENDS IN MOLECULAR MEDICINE, 2018, 24 (03) :257-277
[4]   Cancer stem cells as key drivers of tumour progression [J].
Ayob, Ain Zubaidah ;
Ramasamy, Thamil Selvee .
JOURNAL OF BIOMEDICAL SCIENCE, 2018, 25
[5]   Modeling the initiation and progression of human acute leukemia in mice [J].
Barabe, Frederic ;
Kennedy, James A. ;
Hope, Kristin J. ;
Dick, John E. .
SCIENCE, 2007, 316 (5824) :600-604
[6]   PARENTAL IMPRINTING OF THE MOUSE H19 GENE [J].
BARTOLOMEI, MS ;
ZEMEL, S ;
TILGHMAN, SM .
NATURE, 1991, 351 (6322) :153-155
[7]   Cancer stem cells revisited [J].
Batlle, Eduard ;
Clevers, Hans .
NATURE MEDICINE, 2017, 23 (10) :1124-1134
[8]   A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer [J].
Bu, Pengcheng ;
Wang, Lihua ;
Chen, Kai-Yuan ;
Srinivasan, Tara ;
Murthy, Preetish Kadur Lakshminarasimha ;
Tung, Kuei-Ling ;
Varanko, Anastasia Kristine ;
Chen, Huanhuan Joyce ;
Ai, Yiwei ;
King, Sarah ;
Lipkin, Steven M. ;
Shen, Xiling .
CELL STEM CELL, 2016, 18 (02) :189-202
[9]   Deregulated expression of the imprinted DLK1-DIO3 region in glioblastoma stemlike cells: tumor suppressor role of lncRNA MEG3 [J].
Buccarelli, Mariachiara ;
Lulli, Valentina ;
Giuliani, Alessandro ;
Signore, Michele ;
Martini, Maurizio ;
D'Alessandris, Quintino G. ;
Giannetti, Stefano ;
Novelli, Agnese ;
Ilari, Ramona ;
Giurato, Giorgio ;
Boe, Alessandra ;
Castellani, Giorgia ;
Spartano, Serena ;
Marangi, Giuseppe ;
Biffoni, Mauro ;
Genuardi, Maurizio ;
Pallini, Roberto ;
Marziali, Giovanna ;
Ricci-Vitiani, Lucia .
NEURO-ONCOLOGY, 2020, 22 (12) :1771-1784
[10]  
Casas-Selves Matias, 2011, Evolution (N Y), V4, P624