Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

被引：28

作者：

Assadpour, Elham ^{[1
,2
]}

Rezaei, Atefe ^{[3
]}

Das, Sabya Sachi ^{[4
,5
]}

Rao, Balaga Venkata Krishna ^{[4
]}

Singh, Sandeep Kumar ^{[4
]}

Kharazmi, Mohammad Saeed ^{[6
]}

Jha, Niraj Kumar ^{[7
,8
]}

Jha, Saurabh Kumar ^{[7
,9
,10
]}

Prieto, Miguel A. A. ^{[11
]}

Jafari, Seid Mahdi ^{[11
,12
,13
]}

机构：

[1] Food Ind Res Co, 15739, Gorgan, Iran

[2] Gorgan Univ Agr Sci & Nat Resources, Food & Bionanotech Int Res Ctr Fabiano, 15739, Gorgan, Iran

[3] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Food Sci & Technol, 73461, Esfahan, Iran

[4] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Mesra 835215, Ranchi, India

[5] DIT Univ, Sch Pharmaceut & Populat Hlth Informat, Dehra Dun 248009, India

[6] Univ Calif Riverside, Fac Med, Riverside, CA 92679 USA

[7] Sharda Univ, Sch Engn & Technol SET, Dept Biotechnol, Greater Noida 201310, India

[8] Lovely Profess Univ, Sch Bioengn & Biosci, Phagwara 144411, India

[9] Chandigarh Univ, Dept Biotechnol Engn & Food Technol, Mohali 140413, India

[10] Uttaranchal Univ, Sch Appl & Life Sci SALS, Dept Biotechnol, Dehra Dun 248007, India

[11] Univ Vigo, Fac Sci, Dept Analyt Chem & Food Sci, Nutr & Bromatol Grp, E-32004 Orense, Spain

[12] Gorgan Univ Agr Sci & Nat Resources, Dept Food Mat & Proc Design Engn, 43464, Gorgan, Iran

[13] Hebei Agr Univ, Coll Food Sci & Technol, Baoding 071001, Peoples R China

来源：

PHARMACEUTICALS | 2023年 / 16卷 / 04期

关键词：

Cannabis sativa; cannabidiol; molecular mechanism; bioavailability; nanomedicine; HEALTHY-VOLUNTEERS; DELIVERY-SYSTEM; DOUBLE-BLIND; OPEN-LABEL; CANNABINOIDS; BIOAVAILABILITY; FORMULATION; NANOPARTICLES; MICROSPHERES; RECEPTORS;

D O I：

10.3390/ph16040487

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD.

引用

页数：26

共 110 条

[1] Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different Chemotypes [J].