PANoptosis: A Cell Death Characterized by Pyroptosis, Apoptosis, and Necroptosis

被引：56

作者：

Shi, Chunxia ^{[1
]}

Cao, Pan ^{[1
]}

Wang, Yukun ^{[1
]}

Zhang, Qingqi ^{[1
]}

Zhang, Danmei ^{[1
]}

Wang, Yao ^{[1
]}

Wang, Luwen ^{[1
]}

Gong, Zuojiong ^{[1
,2
]}

机构：

[1] Wuhan Univ, Dept Infect Dis, Renmin Hosp, Wuhan, Peoples R China

[2] Wuhan Univ, Dept Infect Dis, Renmin Hosp, 238 Jiefang Rd, Wuhan 430060, Peoples R China

来源：

JOURNAL OF INFLAMMATION RESEARCH | 2023年 / 16卷

基金：

中国国家自然科学基金;

关键词：

PANoptosis; pyroptosis; apoptosis; necroptosis; ENDOPLASMIC-RETICULUM STRESS; INFLAMMASOME ACTIVATION; INDUCE PYROPTOSIS; MOLECULAR SWITCH; INNATE IMMUNITY; REGULATOR; LETHALITY; CASPASE-8; CLEAVAGE; DOMAIN;

D O I：

10.2147/JIR.S403819

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

PANoptosis is a new cell death proposed by Malireddi et al in 2019, which is characterized by pyroptosis, apoptosis and necroptosis, but cannot be explained by any of them alone. The interaction between pyroptosis, apoptosis and necroptosis is involved in PANoptosis. In this review, from the perspective of PANoptosis, we focus on the relationship between pyroptosis, apoptosis and necroptosis, the key molecules in the process of PANoptosis and the formation of PANoptosome, as well as the role of PANoptosis in diseases. We aim to understand the mechanism of PANoptosis and provide a basis for targeted intervention of PANoptosis-related molecules to treat human diseases.

引用

页码：1523 / 1532

页数：10

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