Preparation and characterization of 3D-printed antibacterial hydrogel with benzyl isothiocyanate

被引:12
作者
Liang, Yunxia [1 ]
Chitrakar, Bimal [2 ]
Liu, Zhenbin [1 ]
Ming, Xujia [1 ]
Xu, Dan [1 ]
Mo, Haizhen [1 ]
Shi, Chunyang [1 ]
Zhu, Xiaolin [1 ]
Hu, Liangbin [1 ]
Li, Hongbo [1 ]
机构
[1] Shaanxi Univ Sci & Technol, Sch Food Sci & Engn, Xian 710021, Peoples R China
[2] Hebei Agr Univ, Coll Food Sci & Technol, Baoding 071001, Hebei, Peoples R China
基金
中国国家自然科学基金;
关键词
Antibacterial hydrogel; Benzyl isothiocyanate; 3D printing; Rheological properties; Staphylococcus aureus; Escherichia coli; STAPHYLOCOCCUS-AUREUS; PAPAYA SEED; IN-VITRO; INFECTION;
D O I
10.18063/ijb.v9i2.671
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Benzyl isothiocyanate (BITC) is an isothiocyanate of plant origin, especially the mustard family, which has good antibacterial properties. However, its applications are challenging due to its poor water solubility and chemical instability. We used food hydrocolloids, including xanthan gum, locust bean gum, konjac glucomannan, and carrageenan as three-dimensional (3D)-printing food ink base and successfully prepared 3D-printed BITC antibacterial hydrogel (BITC-XLKC-Gel). The characterization and fabrication procedure of BITC-XLKC-Gel was studied. The results show that BITC-XLKC-Gel hydrogel has better mechanical properties by low-field nuclear magnetic resonance (LF-NMR), mechanical properties, and rheometer analysis. The strain rate of BITC-XLKC-Gel hydrogel is 76.5%, which is better than that of human skin. Scanning electron microscope (SEM) analysis showed that BITC-XLKC-Gel has uniform pore size and provides a good carrier environment for BITC carriers. In addition, BITC-XLKC-Gel has good 3D-printing performance, and 3D printing can be used for customizing patterns. Finally, inhibition zone analysis showed that the BITC-XLKC-Gel added with 0.6% BITC had strong antibacterial activity against Staphylococcus aureus and the BITC-XLKC-Gel added with 0.4% BITC had strong antibacterial activity against Escherichia coli. Antibacterial wound dressing has always been considered essential in burn wound healing. In experiments that simulated burn infection, BITC-XLKC-Gel showed good antimicrobial activity against methicillin-resistant S. aureus. BITC-XLKC-Gel is a good 3D-printing food ink attributed to strong plasticity, high safety profile, and good antibacterial performance and has great application prospects.
引用
收藏
页码:331 / 343
页数:13
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