Neuroprotective potential of cannabidiol: Molecular mechanisms and clinical implications

被引：17

作者：

Tambe, Srushti M. ^{[1
]}

Mali, Suraj ^{[2
]}

Amin, Purnima D. ^{[1
]}

Oliveira, Mozaniel ^{[3
]}

机构：

[1] Inst Chem Technol, Dept Pharmaceut Sci & Technol, Mumbai 400019, India

[2] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, India

[3] Museu Paraense Emilio Goeldi, Adolpho Ducke Lab, BR-66077830 Belem, Para, Brazil

来源：

JOURNAL OF INTEGRATIVE MEDICINE-JIM | 2023年 / 21卷 / 03期

关键词：

Cannabis sativa; Cannabidiol; Natural products; Bioactive compounds; Anti-neurodegenerative diseases; WNT/BETA-CATENIN PATHWAY; OXIDATIVE STRESS; UP-REGULATION; PPAR-GAMMA; RECEPTOR; EPILEPSY; TARGETS; CELLS; NEUROINFLAMMATION; INFLAMMATION;

D O I：

10.1016/j.joim.2023.03.004

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Cannabidiol (CBD), a nonpsychotropic phytocannabinoid that was once largely disregarded, is currently the subject of significant medicinal study. CBD is found in Cannabis sativa, and has a myriad of neuropharmacological impacts on the central nervous system, including the capacity to reduce neuroinflammation, protein misfolding and oxidative stress. On the other hand, it is well established that CBD generates its biological effects without exerting a large amount of intrinsic activity upon cannabinoid receptors. Because of this, CBD does not produce undesirable psychotropic effects that are typical of marijuana derivatives. Nonetheless, CBD displays the exceptional potential to become a supplementary medicine in various neurological diseases. Currently, many clinical trials are being conducted to investigate this possibility. This review focuses on the therapeutic effects of CBD in managing neurological disorders like Alzheimer's disease, Parkinson's disease and epilepsy. Overall, this review aims to build a stronger understanding of CBD and provide guidance for future fundamental scientific and clinical investigations, opening a new therapeutic window for neuroprotection.Please cite this article as: Tambe SM, Mali S, Amin PD, Oliveira M. Neuroprotective potential of Cannabidiol: Molecular mechanisms and clinical implications. J Integr Med. 2023; 21(3): 236-244 & COPY; 2023 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. All rights reserved.

引用

页码：236 / 244

页数：9

共 50 条

[21] Move Your Body toward Healthy Aging: Potential Neuroprotective Mechanisms of Irisin in Alzheimer's Disease [J].

Bellettini-Santos, Tatiani ;

Batista-Silva, Hemily ;

Marcolongo-Pereira, Clairton ;

de Abreu Quintela-Castro, Fernanda Cristina ;

Barcelos, Rafael Mazioli ;

Mota Braga Chiepe, Kelly Cristina ;

Rossoni, Joamyr Victor ;

Passamani-Ambrosio, Roberta ;

da Silva, Bruno Spalenza ;

Chiarelli-Neto, Orlando ;

Garcez, Michelle Lima .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (15)

[22] INHIBITION OF THE COMPLEMENT SYSTEM BY GLUTATHIONE: MOLECULAR MECHANISMS AND POTENTIAL THERAPEUTIC IMPLICATIONS [J].

Perricone, C. ;

De Carolis, C. ;

Giacomelli, R. ;

Greco, E. ;

Cipriani, P. ;

Ballanti, E. ;

Novelli, L. ;

Perricone, R. .

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 2011, 24 (01) :63-68

[23] Sirtuin Modulators: Mechanisms and Potential Clinical Implications [J].

Sanchez-Fidalgo, S. ;

Villegas, I. ;

Sanchez-Hidalgo, M. ;

Alarcon-de-la-Lastra, Catalina .

CURRENT MEDICINAL CHEMISTRY, 2012, 19 (15) :2414-2441

[24] Inflammation and arrhythmias: potential mechanisms and clinical implications [J].

Lewek, Joanna ;

Kaczmarek, Krzysztof ;

Cygankiewicz, Iwona ;

Wranicz, Jerzy K. ;

Ptaszynski, Pawel .

EXPERT REVIEW OF CARDIOVASCULAR THERAPY, 2014, 12 (09) :1077-1085

[25] Pharmacological effects of cannabidiol by transient receptor potential channels [J].

Etemad, Leila ;

Karimi, Gholamreza ;

Alavi, Mohaddeseh Sadat ;

Roohbakhsh, Ali .

LIFE SCIENCES, 2022, 300

[26] Neuroinflammatory mechanisms of hypertension: potential therapeutic implications [J].

Winklewski, Pawel J. ;

Radkowski, Marek ;

Demkow, Urszula .

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2016, 25 (05) :410-416

[27] Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders [J].

Campos, Alline C. ;

Fogaca, Manoela V. ;

Scarante, Franciele F. ;

Joca, Smia R. L. ;

Sales, Amanda J. ;

Gomes, Felipe V. ;

Sonego, Andreza B. ;

Rodrigues, Naielly S. ;

Galve-Roperh, Ismael ;

Guimaraes, Francisco S. .

FRONTIERS IN PHARMACOLOGY, 2017, 8

[28] The Potential Mechanisms of the Neuroprotective Actions of Oil Palm Phenolics: Implications for Neurodegenerative Diseases [J].

Ibrahim, Nurul 'Izzah ;

Muhammad Ismail Tadj, Nur Balqis ;

Rahman Sarker, Md. Moklesur ;

Naina Mohamed, Isa .

MOLECULES, 2020, 25 (21)

[29] The Human Glucocorticoid Receptor Beta: From Molecular Mechanisms to Clinical Implications [J].

Nicolaides, Nicolas C. .

ENDOCRINOLOGY, 2022, 163 (11)

[30] Epigallocatechin-3-gallate therapeutic potential in human diseases: molecular mechanisms and clinical studies [J].

Alam, Manzar ;

Gulzar, Mehak ;

Akhtar, Mohammad Salman ;

Rashid, Summya ;

Zulfareen, Anas ;

Tanuja, Md. Imtaiyaz ;

Shamsi, Anas ;

Hassan, Md. Imtaiyaz .

MOLECULAR BIOMEDICINE, 2024, 5 (01)

← 1 2 3 4 5 →