Pancreatic Diffuse Large B-cell Lymphoma in the

被引：3

作者：

Ullah, Asad ^{[1
]}

Lee, Kue T. ^{[2
]}

Malham, Kali ^{[3
]}

Yasinzai, Abdul Qahar Khan ^{[4
]}

Tareen, Bisma ^{[5
]}

Lopes, Dara ^{[6
]}

Wali, Agha ^{[5
]}

Zarate, Luis Velasquez ^{[7
]}

Waheed, Abdul ^{[6
]}

Wiest, Maya ^{[6
]}

Hakim, Resham ^{[8
]}

Khan, Marjan ^{[9
]}

Asif, Bina ^{[10
]}

Patel, Nikhil ^{[7
]}

Hakim, Sahar ^{[11
]}

Kakar, Kaleemullah ^{[5
]}

Heneidi, Saleh ^{[12
]}

Karki, Nabin R. ^{[13
]}

Sidhwa, Feroze ^{[14
]}

机构：

[1] Vanderbilt Univ, Pathol, Med Ctr, Nashville, TN 37232 USA

[2] Augusta Univ, Med Coll Georgia, Otolaryngol, Augusta, GA USA

[3] Augusta Univ, Med Coll Georgia, Gastroenterol, Augusta, GA USA

[4] Bolan Med Coll, Surg, Quetta, Pakistan

[5] Bolan Med Coll, Internal Med, Quetta, Pakistan

[6] San Joaquin Gen Hosp, French Camp, CA USA

[7] Augusta Univ, Med Coll Georgia, Pathol, Augusta, GA USA

[8] San Joaquin Gen Hosp, Internal Med, French Camp, CA USA

[9] Marshfield Clin Fdn Med Res & Educ, Internal Med, Marshfield, WI USA

[10] Bannu Med Coll, Med, Bannu, Pakistan

[11] San Joaquin Gen Hosp, Cardiol, French Camp, CA USA

[12] Cedars Sinai Med Ctr, Pathol, Los Angeles, CA USA

[13] Univ S Alabama, Mitchell Canc Inst, Oncol, Mobile, AL USA

[14] San Joaquin Gen Hosp, Gen Surg Trauma & Crit Care, French Camp, CA USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 06期

关键词：

multivariable analysis; chemotherapy; seer; diffuse large b -cell lymphoma; pancreatic lymphomas; DIAGNOSIS; RITUXIMAB;

D O I：

10.7759/cureus.39862

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Results: The most common age group was between the ages of 70 and 79 years (27.0%). While 44% of cases involved distant sites (a proxy for secondary pancreatic DLBCL), regional and localized involvement was seen in 33%, with the most common cause of death being a primary pancreatic DLBCL. Most patients (71%) received only chemotherapy (systemic therapy). The overall five-year observed survival was 46% (95% CI, 43.5-48.3). The one-year and five-year survival with chemotherapy only was 68% (95% CI, 65.3-70.3) and 48% (95% CI, 44.7-50.5), respectively. The one-year and five-year survival with surgery and chemotherapy was 96% (95% CI, 91.3-99.9) and 80% (95% CI, 71.4-89.2), respectively. Surgery with chemotherapy (HR: 0.397 (95% CI, 0.197-0.803), p = 0.010) were both positive predictors in survival prognosis. Multivariable analysis identified age >55 years (HR: 2.475 (95% CI, 1.770-3.461), p < 0.001), distant stage (HR: 6.894 (95% CI, 4.121-11.535), p < 0.001), and undergoing no surgery (HR: 2.610 (95% CI, 1.307-5.215), p = 0.007) as negative predictors for survival.

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