The ChemoArchiChip: Interrogating the response of macrophages to the chemistry and geometry of microscale 3D objects

被引：0
作者：
Frith, Jessica E. [1 ,2 ]
机构：
[1] Monash Univ, Dept Mat Sci & Engn, Clayton, Vic 3800, Australia
[2] Monash Univ, ARC Training Ctr Cell & Tissue Engn Technol, Clayton, Vic 3800, Australia
来源：
MATTER | 2023年 / 6卷 / 04期
关键词：
INTERPLAY;
D O I：
10.1016/j.matt.2023.02.004
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Effective integration of biomedical implants requires understanding and control of interactions between cells and the implant surface. High-throughput screening and modeling can identify properties that elicit desired cell behaviors and reveal patterns to underpin the future development of general design rules. Recently in Matter, Vassey et al. developed the ChemoArchiChip to investigate effects of microscale 3D objects with varied material chemistry on the adhe-sion and polarization of macrophages. The study shows the power of screening and modeling to generate understanding of cell-biomate-rial interactions and provides specific knowledge of conditions to modulate the macrophage response.
引用
收藏
页码：1058 / 1060
页数：3
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