GDF-15 and soluble ST2 as biomarkers of right ventricular dysfunction in pulmonary hypertension

被引：5
作者：
Keranov, Stanislav [1 ,2 ]
Widmann, Laila [1 ]
Jafari, Leili [3 ]
Liebetrau, Christoph [4 ]
Keller, Till [1 ,2 ,3 ]
Troidl, Christian [2 ,3 ]
Kriechbaum, Steffen [2 ,3 ]
Voss, Sandra [2 ,3 ]
Bauer, Pascal [1 ]
Richter, Manuel J. [5 ]
Tello, Khodr [5 ]
Gall, Henning [5 ]
Ghofrani, Hossein A. [5 ]
Wiedenroth, Christoph B. [6 ]
Guth, Stefan [6 ]
Seeger, Werner [5 ]
Hamm, Christian W. [1 ,2 ,3 ]
Nef, Holger [1 ,2 ]
Dorr, Oliver [1 ,2 ]
机构：
[1] Univ Giessen, Dept Cardiol & Angiol, D-35392 Giessen, Germany
[2] German Ctr Cardiovasc Res DZHK, Partner Site RheinMain, D-61231 Bad Nauheim, Germany
[3] Kerckhoff Heart & Lung Ctr, Dept Cardiol, D-61231 Bad Nauheim, Germany
[4] Cardioangiol Ctr Bethanien CCB, D-60389 Frankfurt, Germany
[5] Justus Liebig Univ Giessen, Univ Giessen & Marburg Lung Ctr UGMLC, German Ctr Lung Res DZL, Dept Internal Med,Cardiopulm Inst CPI,Inst Lung H, D-35392 Giessen, Germany
[6] Kerckhoff Heart & Lung Ctr, Dept Thorac Surg, D-61231 Bad Nauheim, Germany
来源：
BIOMARKERS IN MEDICINE | 2022年 / 16卷 / 17期
关键词：
biomolecules; chronic thromboembolic pulmonary hypertension; dilated cardiomyopathy; fibrosis; heart failure; idiopathic pulmonary arterial hypertension; left ventricular hypertrophy; right ventricular-pulmonary arterial coupling; right ventricular maladaptation; right ventricular remodeling; GROWTH-DIFFERENTIATION FACTOR-15; CHRONIC HEART-FAILURE; PROGNOSTIC VALUE; SURVIVAL; ASSOCIATION; SUPPRESSION; EXPRESSION; GALECTIN-3; RECEPTOR; OUTCOMES;
D O I：
10.2217/bmm-2022-0395
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background: This study analyzed the utility of soluble ST2 (sST2) and GDF-15 as biomarkers of right ventricular (RV) function in patients with pulmonary hypertension (PH). Methods: GDF-15 and sST2 serum concentrations were measured in patients with PH (n = 628), dilated cardiomyopathy (n = 31) and left ventricular hypertrophy (n = 47), and in healthy controls (n = 61). Results: Median sST2 and GDF-15 levels in patients with left ventricular hypertrophy were higher than in patients with PH and dilated cardiomyopathy. In tertile analysis GDF-15 >1363 pg/ml and sST2 >38 ng/ml were associated with higher N-terminal pro-brain natriuretic peptide, RV systolic dysfunction, RV-pulmonary arterial uncoupling and hemodynamic impairment. Conclusion: GDF-15 and sST2 are potential biomarkers of RV dysfunction in patients with PH.
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收藏
页码：1193 / 1207
页数：15
相关论文
共 51 条
[1]   Clinical and Prognostic Significance of sST2 in Heart Failure JACC Review Topic of the Week [J].
Aimo, Alberto ;
Januzzi, James L., Jr. ;
Bayes-Genis, Antoni ;
Vergaro, Giuseppe ;
Sciarrone, Paolo ;
Passino, Claudio ;
Emdin, Michele .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 74 (17) :2193-2203
[2]   Prognostic Value of Soluble Suppression of Tumorigenicity-2 in Chronic Heart Failure A Meta-Analysis [J].
Aimo, Alberto ;
Vergaro, Giuseppe ;
Passino, Claudio ;
Ripoli, Andrea ;
Ky, Bonnie ;
Miller, Wayne L. ;
Bayes-Genis, Antoni ;
Anand, Inder ;
Januzzi, James L. ;
Emdin, Michele .
JACC-HEART FAILURE, 2017, 5 (04) :280-286
[3]   Serum soluble ST2 and interleukin-33 levels in patients with pulmonary arterial hypertension [J].
Carlomagno, Guido ;
Messalli, Giancarlo ;
Melillo, Rosa Marina ;
Stanziola, Anna Agnese ;
Visciano, Carla ;
Mercurio, Valentina ;
Imbriaco, Massimo ;
Ghio, Stefano ;
Sofia, Matteo ;
Bonaduce, Domenico ;
Fazio, Serafino .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2013, 168 (02) :1545-1547
[4]   Soluble ST2 Is Associated with All-Cause and Cardiovascular Mortality in a Population-Based Cohort: The Dallas Heart Study [J].
Chen, Lu Q. ;
de Lemos, James A. ;
Das, Sandeep R. ;
Ayers, Colby R. ;
Rohatgi, Anand .
CLINICAL CHEMISTRY, 2013, 59 (03) :536-546
[5]   Structural Heart Disease and ST2: Cross-Sectional and Longitudinal Associations With Echocardiography [J].
defilippi, Christopher ;
Daniels, Lori B. ;
Bayes-Genis, Antoni .
AMERICAN JOURNAL OF CARDIOLOGY, 2015, 115 (07) :59B-63B
[6]   sST2 Predicts Outcome in Chronic Heart Failure Beyond N-proBNP and High-Sensitivity Troponin T [J].
Emdin, Michele ;
Aimo, Alberto ;
Vergaro, Giuseppe ;
Bayes-Genis, Antoni ;
Lupon, Josep ;
Latini, Roberto ;
Meessen, Jennifer ;
Anand, Inder S. ;
Cohn, Jay N. ;
Gravning, Jorgen ;
Gullestad, Lars ;
Broch, Kaspar ;
Ueland, Thor ;
Nymo, Stale H. ;
Rocca, Hans-Peter Brunner-La ;
de Boer, Rudolf A. ;
Gaggin, Hanna K. ;
Ripoli, Andrea ;
Passino, Claudio ;
Januzzi, James L., Jr. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018, 72 (19) :2309-2320
[7]   The Giessen Pulmonary Hypertension Registry: Survival in pulmonary hypertension subgroups [J].
Gall, Henning ;
Felix, Janine F. ;
Schneck, Franziska K. ;
Milger, Katrin ;
Sommer, Natascha ;
Voswinckel, Robert ;
Franco, Oscar H. ;
Hofman, Albert ;
Schermuly, Ralph T. ;
Weissmann, Norbert ;
Grimminger, Friedrich ;
Seeger, Werner ;
Ghofrani, Hossein A. .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2017, 36 (09) :957-967
[8]   The Prognostic Value of Soluble ST2 in Adults with Pulmonary Hypertension [J].
Geenen, Laurie W. ;
Baggen, Vivan J. M. ;
Kauling, Robert M. ;
Koudstaal, Thomas ;
Boomars, Karin A. ;
Boersma, Eric ;
Roos-Hesselink, Jolien W. ;
van den Bosch, Annemien E. .
JOURNAL OF CLINICAL MEDICINE, 2019, 8 (10)
[9]   Growth differentiation factor-15 as candidate predictor for mortality in adults with pulmonary hypertension [J].
Geenen, Laurie W. ;
Baggen, Vivan J. M. ;
Kauling, Robert M. ;
Koudstaal, Thomas ;
Boomars, Karin A. ;
Boersma, Eric ;
Roos-Hesselink, Jolien W. ;
van den Bosch, Annemien E. .
HEART, 2020, 106 (06) :467-473
[10]   Prognostic relevance of the echocardiographic assessment of right ventricular function in patients with idiopathic pulmonary arterial hypertension [J].
Ghio, Stefano ;
Klersy, Catherine ;
Magrini, Giulia ;
D'Armini, Andrea Maria ;
Scelsi, Laura ;
Raineri, Claudia ;
Pasotti, Michele ;
Serio, Alessandra ;
Campana, Carlo ;
Vigano, Mario .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2010, 140 (03) :272-278
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