People With Human Immunodeficiency Virus Receiving Suppressive Antiretroviral Therapy Show Typical Antibody Durability After Dual Coronavirus Disease 2019 Vaccination and Strong Third Dose Responses

被引：37

作者：

Lapointe, Hope R. ^{[1
]}

Mwimanzi, Francis ^{[2
]}

Cheung, Peter K. ^{[1
,2
]}

Sang, Yurou ^{[2
]}

Yaseen, Fatima ^{[3
]}

Umviligihozo, Gisele ^{[2
]}

Kalikawe, Rebecca ^{[2
]}

Speckmaier, Sarah ^{[1
]}

Moran-Garcia, Nadia ^{[1
]}

Datwani, Sneha ^{[2
]}

Duncan, Maggie C. ^{[1
,2
]}

Agafitei, Olga ^{[2
]}

Ennis, Siobhan ^{[2
]}

Young, Landon ^{[4
]}

Ali, Hesham ^{[5
]}

Ganase, Bruce ^{[6
]}

Omondi, F. Harrison ^{[1
,2
]}

Dong, Winnie ^{[1
]}

Toy, Junine ^{[1
]}

Sereda, Paul ^{[1
]}

Burns, Laura ^{[7
]}

Costiniuk, Cecilia T. ^{[8
,9
]}

Cooper, Curtis ^{[10
,11
]}

Anis, Aslam H. ^{[12
,13
,14
]}

Leung, Victor ^{[4
,7
,15
]}

Holmes, Daniel T. ^{[7
,15
]}

DeMarco, Mari L. ^{[7
,15
]}

Simons, Janet ^{[7
,15
]}

Hedgcock, Malcolm ^{[16
]}

Prystajecky, Natalie ^{[15
,17
]}

Lowe, Christopher F. ^{[4
,7
,15
]}

Pantophlet, Ralph ^{[2
,3
]}

Romney, Marc G. ^{[4
,7
,15
]}

Barrios, Rolando ^{[1
,12
]}

Guillemi, Silvia ^{[1
,18
]}

Brumme, Chanson J. ^{[1
,19
]}

Montaner, Julio S. G. ^{[1
,19
]}

Hull, Mark ^{[1
,19
]}

Harris, Marianne ^{[1
,18
]}

Niikura, Masahiro ^{[2
]}

Brockman, Mark A. ^{[1
,2
,3
]}

Brumme, Zabrina L. ^{[1
,2
]}

机构：

[1] British Columbia Ctr Excellence HIV AIDS, Vancouver, BC, Canada

[2] Simon Fraser Univ, Fac Hlth Sci, 8888 Univ Dr, Burnaby, BC V5A 1S6, Canada

[3] Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC, Canada

[4] St Pauls Hosp, Div Med Microbiol & Virol, Vancouver, BC, Canada

[5] St Pauls Hosp, John Ruedy Clin, Vancouver, BC, Canada

[6] St Pauls Hosp, AIDS Res Program, Vancouver, BC, Canada

[7] Providence Hlth Care, Dept Pathol & Lab Med, Vancouver, BC, Canada

[8] McGill Univ, Div Infect Dis & Chron Viral Illness Serv, Hlth Ctr, Montreal, PQ, Canada

[9] McGill Univ, Res Inst, Hlth Ctr, Montreal, PQ, Canada

[10] Univ Ottawa, Dept Med, Ottawa, ON, Canada

[11] Ottawa Hosp, Res Inst, Ottawa, ON, Canada

[12] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada

[13] Univ British Columbia, CIHR Canadian HIV Trials Network, Vancouver, BC, Canada

[14] Ctr Hlth Evaluat & Outcome Sci, Vancouver, BC, Canada

[15] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada

[16] Spectrum Hlth, Vancouver, BC, Canada

[17] British Columbia Ctr Dis Control, Publ Hlth Lab, Vancouver, BC, Canada

[18] Univ British Columbia, Fac Med, Dept Family Practice, Vancouver, BC, Canada

[19] Univ British Columbia, Dept Med, Vancouver, BC, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 2023年 / 227卷 / 07期

基金：

英国惠康基金; 美国国家卫生研究院; 加拿大健康研究院; 加拿大创新基金会;

关键词：

HIV; COVID-19; vaccines; immune response; humoral; antibodies; neutralization; third dose; IMMUNE-RESPONSES; COVID-19; VACCINE; HIV-INFECTION; SARS-COV-2; SAFETY; IMMUNOGENICITY; COHORT; DEATH;

D O I：

10.1093/infdis/jiac229

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

People living with human immunodeficiency virus with well-controlled viral loads on antiretroviral therapy and preserved CD4(+) T-cell counts mount strong, functional antibody responses to 2- and 3-dose coronavirus disease 2019 vaccination, including to Omicron. Monitoring responses over time remains important. Background Longer-term humoral responses to 2-dose coronavirus disease 2019 (COVID-19) vaccines remain incompletely characterized in people living with human immunodeficiency virus (HIV) (PLWH), as do initial responses to a third dose. Methods We measured antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein receptor-binding domain, angiotensin-converting enzyme 2 (ACE2) displacement, and viral neutralization against wild-type and Omicron strains up to 6 months after 2-dose vaccination, and 1 month after the third dose, in 99 PLWH receiving suppressive antiretroviral therapy and 152 controls. Results Although humoral responses naturally decline after 2-dose vaccination, we found no evidence of lower antibody concentrations or faster rates of antibody decline in PLWH compared with controls after accounting for sociodemographic, health, and vaccine-related factors. We also found no evidence of poorer viral neutralization in PLWH after 2 doses, nor evidence that a low nadir CD4(+) T-cell count compromised responses. Post-third-dose humoral responses substantially exceeded post-second-dose levels, though Omicron-specific responses were consistently weaker than responses against wild-type virus. Nevertheless, post-third-dose responses in PLWH were comparable to or higher than controls. An mRNA-1273 third dose was the strongest consistent correlate of higher post-third-dose responses. Conclusion PLWH receiving suppressive antiretroviral therapy mount strong antibody responses after 2- and 3-dose COVID-19 vaccination. Results underscore the immune benefits of third doses in light of Omicron.

引用

页码：838 / 849

页数：12

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