Prognostic value of whole-body dynamic 18F-FDG PET/CT Patlak in diffuse large B-cell lymphoma

被引：4
作者：
Yin, Jiankang [1 ]
Wang, Hui [2 ]
Zhu, Gan [2 ]
Chen, Ni [1 ]
Khan, Muhammad Imran [3 ,4 ,5 ,6 ]
Zhao, Ye [1 ]
机构：
[1] Anhui Med Univ, Sch Basic Med Sci, Hefei, Peoples R China
[2] Anhui Med Univ, Affiliated Hosp 1, Dept Nucl Med, Hefei 230032, Anhui, Peoples R China
[3] Univ Sci & Technol China, Sch Life Sci & Med, Hefei 230026, Anhui, Peoples R China
[4] Dist Headquarters Hosp, Dept Pathol, Jhang 35200, Punjab, Pakistan
[5] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
[6] Univ Sci & Technol China, Ctr Biomed Engn, Hefei 230026, Anhui, Peoples R China
来源：
HELIYON | 2023年 / 9卷 / 09期
关键词：
Whole -body dynamic PET/CT; Patlak; Diffuse large B -Cell lymphoma; 18; F; fluorodeoxyglucose; RESPONSE ASSESSMENT; F-18-FDG PET/CT;
D O I：
10.1016/j.heliyon.2023.e19749
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Objective: This study aims to investigate the significance of interim whole-body dynamic 18Ffluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) Patlak parameters for predicting the prognosis of patients with diffuse large B-cell lymphoma. To estimate the predictive value of the whole-body dynamic 18F-FDG PET/CT Patlak parameter for 2year progression-free survival (PFS) and 2-year overall survival (OS). Methods: This study reports the findings of 67 patients with diffuse large B-cell lymphoma (DLBCL). These patients underwent interim whole-body dynamic 18F-FDG PET/CT scans from June 2021 to January 2023 at the Department of Nuclear Medicine, First Affiliated Hospital of Anhui Medical University. The predictive values of maximum standard uptake value (SUVmax), maximum of net glucose uptake rate (Kimax) and the predictive model combining Kimax and interim treatment response on the prognosis of patients was analyzed using receiver operating characteristic (ROC) curves. Kaplan-Meier survival curves and log-rank tests were used for survival analysis. Univariate and multivariate analyses were performed to screen for independent prognostic risk factors. Results: After a median follow-up of 18 months, 21 patients (31.3%) experienced disease recurrence or death. The cut-off values for the SUVmax and the Kimax were 6.1 and 0.13 mu mol min- 1 & sdot;ml- 1, respectively. Ann Arbor stage, IPI, SUVmax, Kimax and interim treatment response were associated with PFS and OS in the univariate analysis. However, only Kimax and interim treatment response were independent influences on PFS and OS in multivariate analysis. Conclusion: Interim whole-body dynamic 18F-FDG PET/CT Patlak imaging has significant prognostic value in patients with DLBCL. Among them, the interim dynamic parameter Kimax showed the best predictive value for prognosis compared with the interim SUVmax and interim treatment response. The predictive model established by Kimax and the interim treatment response allowed for the accurate stratification of the prognostic risk of DLBCL.
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页数：9
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