NIR-responsive injectable magnesium phosphate bone cement loaded with icariin promotes osteogenesis

被引：6

作者：

Wang, Bin ^{[1
]}

Zhao, Yanbin ^{[2
,3
]}

Li, Yangyang ^{[2
,3
]}

Tang, Chengliang ^{[4
]}

He, Peng ^{[1
]}

Liu, Xiaowei ^{[1
]}

Yao, Junyan ^{[2
,3
]}

Chu, Chenglin ^{[2
,3
]}

Xu, Bin ^{[1
]}

机构：

[1] Nanjing Univ, Jingling Hosp, Med Coll, Dept Orthoped, Nanjing 210002, Jiangsu, Peoples R China

[2] Southeast Univ, Sch Mat Sci & Engn, Nanjing 211189, Peoples R China

[3] Southeast Univ, Jiangsu Key Lab Adv Met Mat, Nanjing 211189, Peoples R China

[4] Huadong Med Inst Biotech, Nanjing 210002, Jiangsu, Peoples R China

来源：

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS | 2024年 / 150卷

基金：

中国国家自然科学基金;

关键词：

Magnesium phosphate bone cement; Mesoporous silica nanoparticles; Near infrared response; Icariin; Osteogenesis; MESOPOROUS SILICA NANOPARTICLES; DRUG-DELIVERY; RELEASE; OSTEOPOROSIS; CELLS;

D O I：

10.1016/j.jmbbm.2023.106256

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

There were defects like limited osteogenesis and fast drug release in traditional magnesium phosphate bone cement (MPC). In this study, we loaded icariin in a mesoporous nano silica container modified by polydopamine and then added it and citric acid into MPC (IHP-CA MPCs). The results indicate that IHP-CA MPCs have a long curing time, almost neutral pH value, excellent injectability, and compressive strength. In vitro experiments have shown that IHP-CA MPCs have good biocompatibility and bone promoting ability. These improvements provide feasible solutions and references for the clinical application of MPCs as implants.

引用

页数：11

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