NIR-responsive injectable magnesium phosphate bone cement loaded with icariin promotes osteogenesis

被引：6

作者：

Wang, Bin ^{[1
]}

Zhao, Yanbin ^{[2
,3
]}

Li, Yangyang ^{[2
,3
]}

Tang, Chengliang ^{[4
]}

He, Peng ^{[1
]}

Liu, Xiaowei ^{[1
]}

Yao, Junyan ^{[2
,3
]}

Chu, Chenglin ^{[2
,3
]}

Xu, Bin ^{[1
]}

机构：

[1] Nanjing Univ, Jingling Hosp, Med Coll, Dept Orthoped, Nanjing 210002, Jiangsu, Peoples R China

[2] Southeast Univ, Sch Mat Sci & Engn, Nanjing 211189, Peoples R China

[3] Southeast Univ, Jiangsu Key Lab Adv Met Mat, Nanjing 211189, Peoples R China

[4] Huadong Med Inst Biotech, Nanjing 210002, Jiangsu, Peoples R China

来源：

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS | 2024年 / 150卷

基金：

中国国家自然科学基金;

关键词：

Magnesium phosphate bone cement; Mesoporous silica nanoparticles; Near infrared response; Icariin; Osteogenesis; MESOPOROUS SILICA NANOPARTICLES; DRUG-DELIVERY; RELEASE; OSTEOPOROSIS; CELLS;

D O I：

10.1016/j.jmbbm.2023.106256

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

There were defects like limited osteogenesis and fast drug release in traditional magnesium phosphate bone cement (MPC). In this study, we loaded icariin in a mesoporous nano silica container modified by polydopamine and then added it and citric acid into MPC (IHP-CA MPCs). The results indicate that IHP-CA MPCs have a long curing time, almost neutral pH value, excellent injectability, and compressive strength. In vitro experiments have shown that IHP-CA MPCs have good biocompatibility and bone promoting ability. These improvements provide feasible solutions and references for the clinical application of MPCs as implants.

引用

页数：11

共 52 条

[31] Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery [J].

Tang, Fangqiong ;

Li, Linlin ;

Chen, Dong .

ADVANCED MATERIALS, 2012, 24 (12) :1504-1534

[32] Synthesis and characterization of biomimetic citrate-based biodegradable composites [J].

Tran, Richard T. ;

Wang, Liang ;

Zhang, Chang ;

Huang, Minjun ;

Tang, Wanjin ;

Zhang, Chi ;

Zhang, Zhongmin ;

Jin, Dadi ;

Banik, Brittany ;

Brown, Justin L. ;

Xie, Zhiwei ;

Bai, Xiaochun ;

Yang, Jian .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2014, 102 (08) :2521-2532

[33] Role of Magnesium in Vitamin D Activation and Function [J].

Uwitonze, Anne Marie ;

Razzaque, Mohammed S. .

JOURNAL OF THE AMERICAN OSTEOPATHIC ASSOCIATION, 2018, 118 (03) :181-189

[34] Accelerated Bone Regeneration by Astragaloside IV through Stimulating the Coupling of Osteogenesis and Angiogenesis [J].

Wang, Feng ;

Qian, Huijuan ;

Kong, Lingchi ;

Wang, Wenbo ;

Wang, Xiaoyu ;

Xu, Ze ;

Chai, Yimin ;

Xu, Jia ;

Kang, Qinglin .

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2021, 17 (07) :1821-1836

[35] Citric acid enhances the physical properties, cytocompatibility and osteogenesis of magnesium calcium phosphate cement [J].

Wang, Shuang ;

Xu, Chao ;

Yu, Suchun ;

Wu, Xiaopei ;

Jie, Zhou ;

Dai, Honglian .

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2019, 94 :42-50

[36] Mesoporous silica nanoparticles in drug delivery and biomedical applications [J].

Wang, Ying ;

Zhao, Qinfu ;

Han, Ning ;

Bai, Ling ;

Li, Jia ;

Liu, Jia ;

Che, Erxi ;

Hu, Liang ;

Zhang, Qiang ;

Jiang, Tongying ;

Wang, Siling .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2015, 11 (02) :313-327

[37] Icariin promotes the proliferation and differentiation of osteoblasts from the rat mandible by the Wnt/β-catenin signalling pathway [J].

Wang, Yue ;

Wang, Ran ;

Zhang, Fengqiu .

MOLECULAR MEDICINE REPORTS, 2018, 18 (03) :3445-3450

[38] Effects of a magnesium adhesive cement on bone stability and healing following a metatarsal osteotomy in horses [J].

Waselau, Martin ;

Samii, Valerie E. ;

Weisbrode, Steven E. ;

Litsky, Alan S. ;

Bertone, Alicia L. .

AMERICAN JOURNAL OF VETERINARY RESEARCH, 2007, 68 (04) :370-378

[39] Self-setting bioactive calcium-magnesium phosphate cement with high strength and degradability for bone regeneration [J].

Wu, Fan ;

Wei, Jie ;

Guo, Han ;

Chen, Fangping ;

Hong, Hua ;

Liu, Changsheng .

ACTA BIOMATERIALIA, 2008, 4 (06) :1873-1884

[40] Tunable stellate mesoporous silica nanoparticles for intracellular drug delivery [J].

Xiong, Lin ;

Du, Xin ;

Shi, Bingyang ;

Bi, Jingxiu ;

Kleitz, Freddy ;

Qiao, Shi Zhang .

JOURNAL OF MATERIALS CHEMISTRY B, 2015, 3 (08) :1712-1721

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