NIR-responsive injectable magnesium phosphate bone cement loaded with icariin promotes osteogenesis

被引：6
作者：
Wang, Bin [1 ]
Zhao, Yanbin [2 ,3 ]
Li, Yangyang [2 ,3 ]
Tang, Chengliang [4 ]
He, Peng [1 ]
Liu, Xiaowei [1 ]
Yao, Junyan [2 ,3 ]
Chu, Chenglin [2 ,3 ]
Xu, Bin [1 ]
机构：
[1] Nanjing Univ, Jingling Hosp, Med Coll, Dept Orthoped, Nanjing 210002, Jiangsu, Peoples R China
[2] Southeast Univ, Sch Mat Sci & Engn, Nanjing 211189, Peoples R China
[3] Southeast Univ, Jiangsu Key Lab Adv Met Mat, Nanjing 211189, Peoples R China
[4] Huadong Med Inst Biotech, Nanjing 210002, Jiangsu, Peoples R China
来源：
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS | 2024年 / 150卷
基金：
中国国家自然科学基金;
关键词：
Magnesium phosphate bone cement; Mesoporous silica nanoparticles; Near infrared response; Icariin; Osteogenesis; MESOPOROUS SILICA NANOPARTICLES; DRUG-DELIVERY; RELEASE; OSTEOPOROSIS; CELLS;
D O I：
10.1016/j.jmbbm.2023.106256
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
There were defects like limited osteogenesis and fast drug release in traditional magnesium phosphate bone cement (MPC). In this study, we loaded icariin in a mesoporous nano silica container modified by polydopamine and then added it and citric acid into MPC (IHP-CA MPCs). The results indicate that IHP-CA MPCs have a long curing time, almost neutral pH value, excellent injectability, and compressive strength. In vitro experiments have shown that IHP-CA MPCs have good biocompatibility and bone promoting ability. These improvements provide feasible solutions and references for the clinical application of MPCs as implants.
引用
收藏
页数：11
相关论文
共 52 条
[1]   Asymmetric Silica Nanoparticles with Tunable Head-Tail Structures Enhance Hemocompatibility and Maturation of Immune Cells [J].
Abbaraju, Prasanna Lakshmi ;
Meka, Anand Kumar ;
Song, Hao ;
Yang, Yannan ;
Jambhrunkar, Manasi ;
Zhang, Jun ;
Xu, Chun ;
Yu, Meihua ;
Yu, Chengzhong .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 139 (18) :6321-6328
[2]   Ultraviolet light-mediated drug delivery: Principles, applications, and challenges [J].
Barhoumi, Aoune ;
Liu, Qian ;
Kohane, Daniel S. .
JOURNAL OF CONTROLLED RELEASE, 2015, 219 :31-42
[3]   Metabolite control of angiogenesis: angiogenic effect of citrate [J].
Binu, S. ;
Soumya, S. J. ;
Sudhakaran, P. R. .
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2013, 69 (03) :383-395
[4]   The biochemical pathway mediating the proliferative response of bone cells to a mechanical stimulus [J].
Brighton, CT ;
Fisher, JRS ;
Levine, SE ;
Corsetti, JR ;
Reilly, T ;
Landsman, AS ;
Williams, JL ;
Thibault, LE .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1996, 78A (09) :1337-1347
[5]   Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions [J].
Castiglioni, Sara ;
Cazzaniga, Alessandra ;
Albisetti, Walter ;
Maier, Jeanette A. M. .
NUTRIENTS, 2013, 5 (08) :3022-3033
[6]   Polyvalent Nucleic Acid/Mesoporous Silica Nanoparticle Conjugates: Dual Stimuli-Responsive Vehicles for Intracellular Drug Delivery [J].
Chen, Cuie ;
Geng, Jie ;
Pu, Fang ;
Yang, Xinjian ;
Ren, Jinsong ;
Qu, Xiaogang .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (04) :882-886
[7]   Osteoblast-osteoclast interactions [J].
Chen, Xiao ;
Wang, Zhongqiu ;
Duan, Na ;
Zhu, Guoying ;
Schwarz, Edward M. ;
Xie, Chao .
CONNECTIVE TISSUE RESEARCH, 2018, 59 (02) :99-107
[8]   PMMA-Based Nanocomposites for Odontology Applications: A State-of-the-Art [J].
Diez-Pascual, Ana M. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (18)
[9]   Magnesium modification up-regulates the bioactivity of bone morphogenetic protein-2 upon calcium phosphate cement via enhanced BMP receptor recognition and Smad signaling pathway [J].
Ding, Sai ;
Zhang, Jing ;
Tian, Yu ;
Huang, Baolin ;
Yuan, Yuan ;
Liu, Changsheng .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2016, 145 :140-151
[10]   Anabolic effects of vitamin D and magnesium in aging bone [J].
Erem, Sarah ;
Atfi, Azeddine ;
Razzaque, Mohammed S. .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2019, 193
123456