Application of eligibility criteria from DAPA-HF, EMPEROR-Reduced, and PARADIGM-HF trials to a population with heart failure with reduced ejection fraction at a specialized cardiology Clinic in Medellin, Colombia: A retrospective cohort study
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作者:
Gonzalez-Franco, Juliana
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机构:
Univ Antioquia, Fac Med, Dept Internal Med, Medellin, Colombia
Direcc km 14 via Las Palmas, Antioquia 055420, ColombiaCardioVID Clin, Medellin, Colombia
Introduction: The evidence supporting pharmacological heart failure treatment relies on randomized clinical trials with stringent inclusion and exclusion criteria. Objectives: Assess the eligibility of outpatients with chronic heart failure for the trials DAPA-HF, EMPEROR-reduced, and PARADIGM-HF, while exploring potential differences among study populations. Methods: By reviewing medical records, we determined the eligibility rate for each study and evaluated the incidence of heart failure hospitalizations and all-cause mortality during this period. Results: A total of 446 patients were included in the cohort. Approximately 75% would be ineligible for the trials, mainly because of their comorbidities. Ineligible patients had a higher allcause mortality, but a similar incidence of hospitalization. Conclusion: Approximately 1 in 4 patients from a heart failure clinic in Medellin, Colombia would meet the eligibility criteria for the DAPA-HF, EMPEROR-reduced, and PARADIGM-HF trials. These findings highlight the need to complement randomized clinical trials with real-world data.
机构:
Papa Giovanni XXIII Hosp, Cardiovasc Dept, Cardiol Div, Bergamo, ItalyPapa Giovanni XXIII Hosp, Cardiovasc Dept, Cardiol Div, Bergamo, Italy
Senni, Michele
Paruchuru, Pratap
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Novartis Pharmaceut, One Hlth Plaza, E Hanover, NJ USAPapa Giovanni XXIII Hosp, Cardiovasc Dept, Cardiol Div, Bergamo, Italy
Paruchuru, Pratap
Shi, Victor
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Novartis Pharmaceut, One Hlth Plaza, E Hanover, NJ USAPapa Giovanni XXIII Hosp, Cardiovasc Dept, Cardiol Div, Bergamo, Italy
Shi, Victor
Boehm, Michael
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Saarland Univ, Med Ctr, Clin Cardiol Angiol & Intens Care Med III, Homburg Saar, GermanyPapa Giovanni XXIII Hosp, Cardiovasc Dept, Cardiol Div, Bergamo, Italy
机构:
Univ Missouri, St Lukes Mid Amer Heart Inst, Kansas City, MO USA
Univ New South Wales, George Inst Global Hlth, Sydney, NSW, AustraliaUniv Glasgow, BHF Cardiovasc Res Ctr, 126 Univ Pl, Glasgow G12 8TA, Lanark, Scotland