Application of eligibility criteria from DAPA-HF, EMPEROR-Reduced, and PARADIGM-HF trials to a population with heart failure with reduced ejection fraction at a specialized cardiology Clinic in Medellin, Colombia: A retrospective cohort study

被引:0
|
作者
Gonzalez-Franco, Juliana [2 ,4 ]
Caicedo-Espinosa, Javier [2 ]
Cardona-Tobon, Carolina [1 ]
Jaramillo-Jara, Natalia [2 ]
Aguilar-Molina, Oswaldo [3 ]
Jaimes-Barragan, Fabian -Alberto [2 ]
Saldarriaga-Giraldo, Clara-Ines [1 ,2 ]
机构
[1] CardioVID Clin, Medellin, Colombia
[2] Univ Antioquia, Fac Med, Dept Internal Med, Medellin, Colombia
[3] Univ Valle, Cali, Colombia
[4] Direcc km 14 via Las Palmas, Antioquia 055420, Colombia
关键词
Heart failure; Eligibility; Dapagliflozin; Empagliflozin; Sacubitril-valsartan; REAL-WORLD; RELAX-AHF; PARTICIPATION;
D O I
10.1016/j.cpcardiol.2023.102193
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: The evidence supporting pharmacological heart failure treatment relies on randomized clinical trials with stringent inclusion and exclusion criteria. Objectives: Assess the eligibility of outpatients with chronic heart failure for the trials DAPA-HF, EMPEROR-reduced, and PARADIGM-HF, while exploring potential differences among study populations. Methods: By reviewing medical records, we determined the eligibility rate for each study and evaluated the incidence of heart failure hospitalizations and all-cause mortality during this period. Results: A total of 446 patients were included in the cohort. Approximately 75% would be ineligible for the trials, mainly because of their comorbidities. Ineligible patients had a higher allcause mortality, but a similar incidence of hospitalization. Conclusion: Approximately 1 in 4 patients from a heart failure clinic in Medellin, Colombia would meet the eligibility criteria for the DAPA-HF, EMPEROR-reduced, and PARADIGM-HF trials. These findings highlight the need to complement randomized clinical trials with real-world data.
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页数:12
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