Focal therapy of prostate cancer: Assessment with prostate-specific membrane antigen (PSMA) imaging

被引：2

作者：

Topoozian, Mark ^{[1
]}

Calais, Jeremie ^{[2
]}

Felker, Ely ^{[3
]}

Sisk, Anthony ^{[4
]}

Gonzalez, Samantha ^{[1
]}

Lee, Sean J. ^{[1
]}

Marks, Leonard S. ^{[1
]}

机构：

[1] David Geffen Sch Med UCLA, Dept Urol, Los Angeles, CA 90024 USA

[2] David Geffen Sch Med UCLA, Dept Nucl Med, Los Angeles, CA USA

[3] David Geffen Sch Med UCLA, Dept Radiol, Los Angeles, CA USA

[4] David Geffen Sch Med UCLA, Dept Pathol, Los Angeles, CA USA

来源：

UROLOGY CASE REPORTS | 2023年 / 50卷

关键词：

Prostate cancer; Focal therapy; PSMA; HIFU;

D O I：

10.1016/j.eucr.2023.102461

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Focal therapy of prostate cancer (PCa) is currently of great interest, but a metric of success. other than biopsy, is not yet available. In a patient with a repeatedly negative MRI and negative systematic biopsies, a scan employing the radioisotope 68Ga-PSMA-11 PET/CT identified a PSMA-avid hotspot in the prostate. PSMA-guided biopsy confirmed the diagnosis of a clinically-significant PCa. Following ablation of the lesion with high-intensity focused ultrasound (HIFU), the PSMA-avid lesion disappeared and targeted biopsy confirmed a fibrotic scar with no residual cancer. PSMA imaging may have a role in guiding diagnosis, focal ablation, and follow-up of men with PCa.

引用

页数：3

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