Maternal periconceptional folic acid supplementation and risk for fetal congenital genitourinary system defects

被引:0
作者
Pang, Zixi [1 ,2 ]
Jin, Lei [1 ,2 ,3 ]
Zhang, Jie [1 ,2 ]
Meng, Wenying [3 ]
Wang, Di [1 ,2 ]
Jin, Lei [1 ,2 ,3 ]
机构
[1] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
[2] Peking Univ, Inst Reprod & Child Hlth, Natl Hlth Commiss Key Lab Reprod Hlth, Beijing 100191, Peoples R China
[3] Tongzhou Maternal & Child Hlth Hosp Beijing, Beijing 101100, Peoples R China
关键词
ANTIEPILEPTIC DRUGS; URINARY-TRACT; BIRTH-DEFECTS; HYPOSPADIAS; ANOMALIES; KIDNEY;
D O I
10.1038/s41390-023-02808-7
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
BackgroundTaking folic acid supplementation could reduce the risk of neural tube defects for offspring in the maternal periconceptional period, but the relationship between folic acid use and other birth defects remains unclear, such as genitourinary system birth defects.MethodsThe data from a Prenatal Health Care System and Birth Defects Surveillance System in Tongzhou, Beijing, China, were collected from 2013 to 2018. We adjusted for differences in characteristics between comparison groups using propensity score inverse probability weighting and assessed associations with Poisson regression modeling.ResultsA total of 65,418 live births and stillbirths were included, and there were 194 cases with congenital genitourinary defects among them. The prevalence of genitourinary system birth defects was 29.2 (34.9) per 10,000 for FA/MMFA users (nonusers). Compared to nonusers, FA/MMFA users had a lower risk for genitourinary system birth defects (adjusted risk ratio [aRR] 0.81, 95% confidence interval [CI] 0.67, 0.98), and for hypospadias (aRR 0.55, 95% CI 0.40, 0.76).ConclusionsFA or MMFA supplementation during the maternal periconceptional period could reduce the risk for genitourinary system birth defects in offspring. More mechanisms should be explored for the protective effect.ImpactFolic acid (FA) or multiple micronutrients containing folic acid (MMFA) supplementation during the maternal periconceptional period could reduce the risk for genitourinary system birth defects in offspring.Maternal FA/MMFA supplementation during the periconceptional period may reduce the risk for hypospadias.
引用
收藏
页码:1132 / 1138
页数:7
相关论文
共 47 条
[1]  
[Anonymous], 1991, Lancet, V338, P131, DOI 10.1016/0140-6736(91)90133-A
[2]   Teratogenic effects of antiepileptic drugs: Use of an international database on malformations and drug exposure (MADRE) [J].
Arpino, C ;
Brescianini, S ;
Robert, E ;
Castilla, EE ;
Cocchi, G ;
Cornel, MC ;
de Vigan, C ;
Lancaster, PAL ;
Merlob, P ;
Sumiyoshi, Y ;
Zampino, G ;
Renzi, C ;
Resano, A ;
Mastroiacovo, P .
EPILEPSIA, 2000, 41 (11) :1436-1443
[3]   Bioengineered tissues for urogenital, repair in children [J].
Atala, Anthony .
PEDIATRIC RESEARCH, 2008, 63 (05) :569-575
[4]   Structural and functional changes in the kidney caused by adverse fetal and neonatal environments [J].
Awazu, Midori .
MOLECULAR BIOLOGY REPORTS, 2022, 49 (03) :2335-2344
[5]   Folic acid supplementation alleviates reduced ureteric branching, nephrogenesis, and global DNA methylation induced by maternal nutrient restriction in rat embryonic kidney [J].
Awazu, Midori ;
Hida, Mariko .
PLOS ONE, 2020, 15 (04)
[6]   Hypospadias: anatomy, etiology, and technique [J].
Baskin, LS ;
Ebbers, MB .
JOURNAL OF PEDIATRIC SURGERY, 2006, 41 (03) :463-472
[7]   Are congenital urinary tract and genital organ anomalies related to folic acid? [J].
Blom, Fenneke ;
Bergman, Jorieke E. H. ;
de Walle, Hermien E. K. .
EUROPEAN UROLOGY, 2016, 69 (03) :544-546
[8]   Hypospadias and Intake of Nutrients Related to One-Carbon Metabolism [J].
Carmichael, Suzan L. ;
Yang, Wei ;
Correa, Adolfo ;
Olney, Richard S. ;
Shaw, Gary M. .
JOURNAL OF UROLOGY, 2009, 181 (01) :315-321
[9]   Variants in ALX4 and their association with genitourinary defects [J].
Chen, Ching H. ;
Bournat, Juan C. ;
Wilken, Nathan ;
Rosenfeld, Jill A. ;
Zhang, Jason ;
Seth, Abhishek ;
Jorgez, Carolina J. .
ANDROLOGY, 2020, 8 (05) :1243-1255
[10]   Association between Folic Acid Supplementation and Hypertensive Disorder Complicating Pregnancy in Jiangsu Province: A Cross-Sectional Study [J].
Cong, Jing ;
Pu, Danhua ;
Tan, Rongrong ;
Ge, Xiaoyun ;
Zhu, Weipei ;
Shen, Cai-e ;
Ge, Jianfen ;
Luo, Xiucui ;
Liu, Juan ;
Wu, Jie .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 2022