Effects of lithium on serum Brain-Derived Neurotrophic Factor in Alzheimer's patients with agitation

被引：1
作者：
Deliyannides, Deborah A. [1 ,2 ]
Graff, Jamie A. [1 ]
Nino, Izael [1 ]
Lee, Seonjoo [2 ,3 ,4 ]
Husain, Mustafa M. [5 ]
Forester, Brent P. [6 ]
Crocco, Elizabeth [7 ]
Vahia, Ipsit V. [6 ]
Devanand, Davangere P. [1 ,2 ,8 ,9 ]
机构：
[1] New York State Psychiat Inst & Hosp, Div Geriatr Psychiat, New York, NY USA
[2] Columbia Univ, Med Ctr, Dept Psychiat, New York, NY USA
[3] Columbia Univ, Med Ctr, Dept Biostat, New York, NY USA
[4] New York State Psychiat Inst & Hosp, Mental Hlth Data Sci, New York, NY USA
[5] Univ Texas Southwestern Med Ctr, Dept Psychiat & Neurol, Dallas, TX USA
[6] Harvard Med Sch, McLean Hosp, Div Geriatr Psychiat, Belmont, MA USA
[7] Univ Miami, Ctr Cognit Neurosci & Aging, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL USA
[8] Columbia Univ, Med Ctr, Dept Neurol, New York, NY 10027 USA
[9] Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, Med Ctr, New York, NY 10027 USA
来源：
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY | 2023年 / 38卷 / 09期
关键词：
agitation; Alzheimer's disease; BDNF; brain-derived neurotrophic factor; dementia; lithium; mild cognitive impairment; neuropsychiatric symptoms; psychiatry; MILD COGNITIVE IMPAIRMENT; TREATMENT INCREASES; FACTOR BDNF; DISEASE; SCHIZOPHRENIA;
D O I：
10.1002/gps.6002
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
BackgroundThere is ample evidence in animal models that lithium increases Brain-Derived Neurotrophic Factor (BDNF) with supporting evidence in human studies. Little is known, however, about the effects of lithium on BDNF in Alzheimer's Dementia (AD). In one study of patients with Mild Cognitive Impairment, serum BDNF increased after treatment with lithium. These patients also showed mild improvement in cognitive function.ObjectivesTo evaluate low-dose lithium treatment of agitation in Alzheimer's disease (AD).MethodWe measured levels of BDNF in patients treated with lithium prior to and after a 12-week randomized placebo-controlled trial.ResultsBDNF levels did not change significantly and were not associated with improvement in overall neuropsychiatric symptoms or in cognitive function.ConclusionsMore research is needed to understand the potential effects of lithium on BDNF in AD including whether its use might be dependent on the stage of cognitive decline and dementia.
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页数：7
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