RNA N6-methyladenosine modification in female reproductive biology and pathophysiology

被引：25

作者：

Huang, Erqing ^{[1
]}

Chen, Lijuan ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Obstet & Gynecol, Wuhan 430022, Peoples R China

来源：

CELL COMMUNICATION AND SIGNALING | 2023年 / 21卷 / 01期

基金：

中国国家自然科学基金;

关键词：

m(6)A methylation; Epigenetic modification; Reproductive disease; Preeclampsia; Endometriosis; Abortion; Gynaecological cancer; MESSENGER-RNA; NUCLEAR-RNA; BINDING-PROTEIN; OVARIAN-CANCER; FTO GENE; METHYLATION; M(6)A; N6-METHYLADENOSINE; DEMETHYLASE; EXPRESSION;

D O I：

10.1186/s12964-023-01078-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gene expression and posttranscriptional regulation can be strongly influenced by epigenetic modifications. N-6-methyladenosine, the most extensive RNA modification, has been revealed to participate in many human diseases. Recently, the role of RNA epigenetic modifications in the pathophysiological mechanism of female reproductive diseases has been intensively studied. RNA m(6)A modification is involved in oogenesis, embryonic growth, and foetal development, as well as preeclampsia, miscarriage, endometriosis and adenomyosis, polycystic ovary syndrome, premature ovarian failure, and common gynaecological tumours such as cervical cancer, endometrial cancer, and ovarian cancer. In this review, we provide a summary of the research results of m(6)A on the female reproductive biology and pathophysiology in recent years and aim to discuss future research directions and clinical applications of m(6)A-related targets. Hopefully, this review will add to our understanding of the cellular mechanisms, diagnostic biomarkers, and underlying therapeutic strategies of female reproductive system diseases.

引用

页数：17

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