Surgical restaging of patients with early-stage endometrial cancer with lymphovascular invasion does not significantly impact their survival outcomes

被引:1
作者
Navarro, Beatriz [1 ]
Margioula-Siarkou, Chrysoula [1 ]
Petousis, Stamatios [1 ,2 ]
Floquet, Anne [1 ]
Babin, Guillame [1 ]
Guyon, Frederic [1 ]
机构
[1] Inst Bergonie, Gynaecol Oncol Unit, F-33076 Bordeaux, France
[2] Inst Bergonie, Gynaecol Oncol Unit, Cours Argonne 229, F-33076 Bordeaux, France
关键词
endometrial cancer; restaging; lymphovascular space invasion; early-stage; lymphadenectomy; VASCULAR SPACE INVASION; LYMPH-NODE METASTASIS; SIGNIFICANT RISK-FACTOR; INVOLVEMENT; RECURRENCE; LVSI;
D O I
10.3892/ol.2023.13708
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Lymphovascular space invasion (LVSI) is considered to be a poor prognostic factor in endometrial cancer. However, management of patients with early-stage endometrial cancer with positive LVSI remains controversial. The main objective of the present study was to investigate whether surgical restaging of such patients has a significant effect on survival outcomes or may be otherwise omitted. A retrospective cohort study was conducted at the Gynaecologic Oncology Unit, Insitut Bergonie, Bordeaux, France for the period January 2003-December 2019. The present study included patients with definitive histopathological diagnosis of early-stage, grade 1-2 endometrial cancer with positive LVSI. Patients were divided into two groups: Those being restaged with pelvic and para-aortic lymphadenectomy (group 1) and those not restaged and receiving complementary therapy (group 2). The primary outcomes of the study were overall survival and progression-free survival. Epidemiological data, clinical and histopathological characteristics as well as complementary treatment received were also studied. Kaplan-Meier and Cox regression analyses were performed. Data from 30 patients were retrieved, of which restaging with lymphadenectomy was performed in 21 patients (group 1), while another 9 patients (group 2) were not restaged and received complementary therapy. Lymph node metastasis was observed in 23.8% of patients in group 1 (n=5). No significant difference was observed between groups 1 and 2 in terms of survival outcomes. The median overall survival was 91.31 months in group 1 and 90.61 months in group 2 [hazard ratio (HR), 0.71; 95% CI, 0.03-16.58; P=0.829]. The median disease-free survival was 87.95 months in group 1 and 81.52 months in group 2 (HR, 0.85; 95% CI, 0.12-5.91; P=0.869). In conclusion, restaging with lymphadenectomy did not alter prognosis of early-stage, LVSI-positive patients. As there was no clinical and therapeutic benefit, restaging with lymphadenectomy could be omitted in such patients.
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页数:5
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