Inflammatory biomarkers of ischemic stroke

被引：44

作者：

Tirandi, Amedeo ^{[1
]}

Sgura, Cosimo ^{[1
]}

Carbone, Federico ^{[1
,2
]}

Montecucco, Fabrizio ^{[1
,2
]}

Liberale, Luca ^{[1
,2
]}

机构：

[1] Univ Genoa, Dept Internal Med, Viale Benedetto XV 6, I-16132 Genoa, Italy

[2] IRCCS Osped Policlin San Martino Genoa, Italian Cardiovasc Network, Largo Rosanna Benzi 10, I-16132 Genoa, Italy

来源：

INTERNAL AND EMERGENCY MEDICINE | 2023年 / 18卷 / 03期

关键词：

Inflammation; Stroke; Adipocytokines; Adhesion molecules; Cytokines; INTERCELLULAR-ADHESION MOLECULE-1; FOCAL CEREBRAL-ISCHEMIA; INTERLEUKIN-1 RECEPTOR ANTAGONIST; P-SELECTIN GENE; BRAIN-INJURY; PLASMA ADIPONECTIN; ARTERY OCCLUSION; LEPTIN LEVELS; SERUM-LEVELS; TNF-ALPHA;

D O I：

10.1007/s11739-023-03201-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ischemic stroke remains the second leading cause of death and among the major causes of morbidity worldwide. Therapeutic options are currently limited to early reperfusion strategies, while pharmacological neuroprotective strategies despite showing promising results in the experimental setting constantly failed to enter the clinical arena. Inflammation plays an important role in the pathophysiology of ischemic stroke and mediators of inflammation have been longtime investigated as possible prognostic marker and therapeutic target for stroke patients. Here, we summarized available evidence on the role of cytokines, soluble adhesion molecules and adipokines in the pathophysiology, prognosis and therapy of ischemic stroke.

引用

页码：723 / 732

页数：10

共 80 条

[31] Anti-VCAM-1 antibodies did not protect against ischemic damage either in rats or in mice [J].

Justicia, C ;

Martín, A ;

Rojas, S ;

Gironella, M ;

Cervera, A ;

Panés, J ;

Chamorro, A ;

Planas, AM .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2006, 26 (03) :421-432

[32] An Explanation for the Adiponectin Paradox [J].

Kalkman, Hans O. .

PHARMACEUTICALS, 2021, 14 (12)

[33] Increased IL-1β, IL-8, and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study [J].

Kostulas, N ;

Pelidou, SH ;

Kivisäkk, P ;

Kostulas, V ;

Link, H .

STROKE, 1999, 30 (10) :2174-2179

[34] Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN) - An adaptive dose-response study of UK-279,276 in acute ischemic stroke [J].

Krams, M ;

Lees, KR ;

Hacke, W ;

Grieve, AP ;

Orgogozo, JM ;

Ford, GA .

STROKE, 2003, 34 (11) :2543-2548

[35] Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS) [J].

Kuwashiro, Takahiro ;

Ago, Tetsuro ;

Kamouchi, Masahiro ;

Matsuo, Ryu ;

Hata, Jun ;

Kuroda, Junya ;

Fukuda, Kenji ;

Sugimori, Hiroshi ;

Fukuhara, Masayo ;

Awano, Hideto ;

Isomura, Tetsu ;

Suzuki, Kazuo ;

Yasaka, Masahiro ;

Okada, Yasushi ;

Kiyohara, Yutaka ;

Kitazono, Takanari .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2014, 63 (09) :1093-1103

[36] Blocking of α4 Integrin Does Not Protect From Acute Ischemic Stroke in Mice [J].

Langhauser, Friederike ;

Kraft, Peter ;

Goeb, Eva ;

Leinweber, Jonas ;

Schuhmann, Michael K. ;

Lorenz, Kristina ;

Gelderblom, Mathias ;

Bittner, Stefan ;

Meuth, Sven G. ;

Wiendl, Heinz ;

Magnus, Tim ;

Kleinschnitz, Christoph .

STROKE, 2014, 45 (06) :1799-+

[37] The Association Between Serum Leptin Levels and Post-Stroke Depression: A Retrospective Clinical Study [J].

Lee, Jin Young ;

Lim, Oh Kyung ;

Lee, Ju Kang ;

Park, Yongbum ;

Kim, Cham ;

Yoon, Jin Won ;

Park, Ki Deok .

ANNALS OF REHABILITATION MEDICINE-ARM, 2015, 39 (05) :786-792

[38] High Serum Levels of Resistin is Associated With Acute Cerebral Infarction [J].

Lee, Kee Ook ;

Lee, Kyung-Yul ;

Lee, Cheol-Young ;

Kim, Ji Hoon ;

Kang, Jaeku ;

Lee, Hoi Young ;

Na, Sang-Jun ;

Oh, Seung-Hun ;

Heo, Ji Hoe .

NEUROLOGIST, 2022, 27 (02) :41-45

[39] Increased Serum E-Selectin Levels Were Associated with Cognitive Decline in Patients with Stroke [J].

Li, Jin ;

Bao, Junqiang ;

Gao, Chao ;

Wei, Zibin ;

Tan, Liguo ;

Liu, Ping ;

Wang, Zhiwei ;

Tian, Shujuan .

INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2021, 14 :733-739

[40] TNF-α antagonism rescues the effect of ageing on stroke: Perspectives for targeting inflamm-ageing [J].

Liberale, Luca ;

Bonetti, Nicole R. ;

Puspitasari, Yustina M. ;

Vukolic, Ana ;

Akhmedov, Alexander ;

Diaz-Canestro, Candela ;

Keller, Stephan ;

Montecucco, Fabrizio ;

Merlini, Mario ;

Semerano, Aurora ;

Giacalone, Giacomo ;

Bacigaluppi, Marco ;

Sessa, Maria ;

Ruschitzka, Frank ;

Luscher, Thomas F. ;

Libby, Peter ;

Beer, Jurg H. ;

Camici, Giovanni G. .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2021, 51 (11)

← 1 2 3 4 5 6 7 8 →