Inflammatory biomarkers of ischemic stroke

被引：44

作者：

Tirandi, Amedeo ^{[1
]}

Sgura, Cosimo ^{[1
]}

Carbone, Federico ^{[1
,2
]}

Montecucco, Fabrizio ^{[1
,2
]}

Liberale, Luca ^{[1
,2
]}

机构：

[1] Univ Genoa, Dept Internal Med, Viale Benedetto XV 6, I-16132 Genoa, Italy

[2] IRCCS Osped Policlin San Martino Genoa, Italian Cardiovasc Network, Largo Rosanna Benzi 10, I-16132 Genoa, Italy

来源：

INTERNAL AND EMERGENCY MEDICINE | 2023年 / 18卷 / 03期

关键词：

Inflammation; Stroke; Adipocytokines; Adhesion molecules; Cytokines; INTERCELLULAR-ADHESION MOLECULE-1; FOCAL CEREBRAL-ISCHEMIA; INTERLEUKIN-1 RECEPTOR ANTAGONIST; P-SELECTIN GENE; BRAIN-INJURY; PLASMA ADIPONECTIN; ARTERY OCCLUSION; LEPTIN LEVELS; SERUM-LEVELS; TNF-ALPHA;

D O I：

10.1007/s11739-023-03201-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ischemic stroke remains the second leading cause of death and among the major causes of morbidity worldwide. Therapeutic options are currently limited to early reperfusion strategies, while pharmacological neuroprotective strategies despite showing promising results in the experimental setting constantly failed to enter the clinical arena. Inflammation plays an important role in the pathophysiology of ischemic stroke and mediators of inflammation have been longtime investigated as possible prognostic marker and therapeutic target for stroke patients. Here, we summarized available evidence on the role of cytokines, soluble adhesion molecules and adipokines in the pathophysiology, prognosis and therapy of ischemic stroke.

引用

页码：723 / 732

页数：10

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