Blood-to-brain communication in aging and rejuvenation

被引：83

作者：

Bieri, Gregor ^{[1
]}

Schroer, Adam B. B. ^{[1
]}

Villeda, Saul A. A. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

[2] Univ Calif San Fransisco, Dept Phys Therapy & Rehabil Sci, San Francisco, CA 94143 USA

[3] Bakar Aging Res Inst, San Francisco, CA 94143 USA

来源：

NATURE NEUROSCIENCE | 2023年 / 26卷 / 03期

关键词：

AGE-RELATED IMPAIRMENTS; HIPPOCAMPAL NEUROGENESIS; CALORIC RESTRICTION; CEREBROSPINAL-FLUID; CHOROID-PLEXUS; SYNAPTIC PLASTICITY; COGNITIVE FUNCTION; IMPROVES MEMORY; BETA-HYDROXYBUTYRATE; ALZHEIMERS-DISEASE;

D O I：

10.1038/s41593-022-01238-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Aging induces molecular, cellular and functional changes in the adult brain that drive cognitive decline and increase vulnerability to dementia-related neurodegenerative diseases. Leveraging systemic and lifestyle interventions, such as heterochronic parabiosis, administration of 'young blood', exercise and caloric restriction, has challenged prevalent views of brain aging as a rigid process and has demonstrated that aging-associated cognitive and cellular impairments can be restored to more youthful levels. Technological advances in proteomic and transcriptomic analyses have further facilitated investigations into the functional impact of intertissue communication on brain aging and have led to the identification of a growing number of pro-aging and pro-youthful factors in blood. In this review, we discuss blood-to-brain communication from a systems physiology perspective with an emphasis on blood-derived signals as potent drivers of both age-related brain dysfunction and brain rejuvenation. In this Review, Villeda and colleagues describe blood-to-brain communication from a systems physiology perspective, with an emphasis on blood-derived signals as potent drivers of both age-related brain dysfunction and brain rejuvenation.

引用

页码：379 / 393

页数：15

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