Non-covalent interactions reveal the protein chain δ conformation in a flexible single-residue model

被引：4

作者：

Imani, Zeynab ^{[1
,5
]}

Mundlapati, Venkateswara Rao ^{[2
,6
]}

Brenner, Valerie ^{[2
]}

Gloaguen, Eric ^{[2
]}

Le Barbu-Debus, Katia ^{[3
]}

Zehnacker-Rentien, Anne ^{[3
]}

Robin, Sylvie ^{[1
,4
]}

Aitken, David J. ^{[1
]}

Mons, Michel ^{[2
]}

机构：

[1] Univ Paris Saclay, ICMMO, CNRS, F-91400 Orsay, France

[2] Univ Paris Saclay, LIDYL, CNRS, CEA, F-91191 Gif Sur Yvette, France

[3] Univ Paris Saclay, ISMO, CNRS, F-91400 Orsay, France

[4] Univ Paris, Fac Pharm, F-75006 Paris, France

[5] Univ Montreal, Dept Chim, Montreal, PQ, Canada

[6] Univ Toulouse, Inst Rech Astrophys & Planetol, Toulouse, France

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 09期

关键词：

HYDROGEN-BOND; INTRAMOLECULAR CATALYSIS;

D O I：

10.1039/d2cc06658k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The delta conformation is a local secondary structure in proteins that implicates a pi(amide) N-HMIDLINE HORIZONTAL ELLIPSISN interaction between a backbone N atom and the NH of the following residue. Small-molecule models thereof have been limited so far to rigid proline-type compounds. We show here that in derivatives of a cyclic amino acid with a sulphur atom in the gamma-position, specific side-chain/backbone N-HMIDLINE HORIZONTAL ELLIPSISS interactions stabilize the delta conformation sufficiently to allow it to compete with classical C5 and C7 H-bonded conformers.

引用

页码：1161 / 1164

页数：4

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