Early recanalization with intravenous thrombolysis before mechanical thrombectomy: considerations to explore with tenecteplase

被引：3

作者：

Hendrix, Philipp ^{[1
,2
,3
]}

Schirmer, Clemens M. ^{[1
,2
]}

机构：

[1] Geisinger, Dept Neurosurg, Wilkes Barre, PA USA

[2] Geisinger, Dept Neurosurg, Danville, PA USA

[3] Geisinger, Dept Neurosurg, Danville, PA 17822 USA

来源：

JOURNAL OF NEUROINTERVENTIONAL SURGERY | 2023年 / 15卷 / 05期

关键词：

Thrombolysis; Thrombectomy; REPERFUSION; ALTEPLASE;

D O I：

10.1136/jnis-2022-019981

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

Time is brain. Hence, timely reperfusion in emergent large vessel occlusion (LVO) stroke is critical for favorable outcomes. Intravenous thrombolysis with alteplase (TPA) before mechanical thrombectomy (MT) for emergent LVO stroke is associated with significantly higher rates of preinterventional reperfusion than MT alone. Recent post hoc analyses of SWIFT-DIRECT and DIRECT-MT have shown that times longer than 30 min since TPA administration are associated with increased reperfusion rates.1 2 The incremental increase of reperfusion rates with longer times since TPA administration underpins TPA's time dependence to exert clot dissolution in emergent LVO strokes. © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

引用

页码：513 / 514

页数：2

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