Prognosis of patients with systemic sclerosis-related interstitial lung disease on the lung transplant waiting list: a retrospective study

被引:4
作者
Nakayama, Yoichi [1 ]
Nakashima, Ran [1 ]
Handa, Tomohiro [2 ,3 ]
Ohsumi, Akihiro [4 ]
Yamada, Yoshito [4 ]
Nakajima, Daisuke [4 ]
Yutaka, Yojiro [4 ]
Tanaka, Satona [4 ]
Hamada, Satoshi [2 ]
Ikezoe, Kohei [3 ]
Tanizawa, Kiminobu [3 ]
Shirakashi, Mirei [1 ]
Hiwa, Ryosuke [1 ]
Tsuji, Hideaki [1 ]
Kitagori, Koji [1 ]
Akizuki, Shuji [1 ]
Yoshifuji, Hajime [1 ]
Date, Hiroshi [4 ]
Morinobu, Akio [1 ]
机构
[1] Kyoto Univ, Grad Sch Med, Dept Rheumatol & Clin Immunol, 54 Kawahara Cho,Sakyo Ku, Kyoto 6068507, Japan
[2] Kyoto Univ, Grad Sch Med, Dept Adv Med Resp Failure, Kyoto, Japan
[3] Kyoto Univ, Grad Sch Med, Dept Resp Med, Kyoto, Japan
[4] Kyoto Univ, Grad Sch Med, Dept Thorac Surg, Kyoto, Japan
关键词
ISHLT CONSENSUS DOCUMENT; PULMONARY-FIBROSIS; INTERNATIONAL GUIDELINES; SELECTION; SURVIVAL; CANDIDATES; RISK; DYSFUNCTION; MORTALITY; CRITERIA;
D O I
10.1038/s41598-023-37141-w
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Advanced systemic sclerosis-associated interstitial lung disease (SSc-ILD) can be treated with lung transplantation. There is limited data on lung transplantation outcomes in patients with SSc-ILD, in non-Western populations.We assessed survival data of patients with SSc-ILD, on the lung transplant (LT) waiting list, and evaluated post-transplant outcomes in patients from an Asian LT center. In this single-center retrospective study, 29 patients with SSc-ILD, registered for deceased LT at Kyoto University Hospital, between 2010 and 2022, were identified. We investigated post-transplant outcomes in recipients who underwent LT for SSc-ILD, between February 2002 and April 2022. Ten patients received deceased-donor LT (34%), two received living-donor LT (7%), seven died waiting for LT (24%), and ten survived on the waiting list (34%). Median duration from registration to deceased-donor LT was 28.9 months and that from registration to living-donor LT or death was 6.5 months. Analysis of 15 recipients showed improved forced vital capacity with a median of 55.1% at baseline, 65.8% at 6 months, and 80.3% at 12 months post-transplant. The 5-year survival rate for post-transplant patients with SSc-ILD was 86.2%. The higher post-transplant survival rate at our institute than previously reported suggests that lung transplantation is acceptable in Asian patients with SSc-ILD.
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页数:10
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