An overview of myelodysplastic syndromes

被引:1
作者
Pontrelli, Gina [1 ]
Loscalzo, Carina [1 ]
L'Eplattenier, Mark [1 ]
机构
[1] Hofstra Univ Hempstead, PA program, Hempstead, NY 11549 USA
来源
JAAPA-JOURNAL OF THE AMERICAN ACADEMY OF PHYSICIAN ASSISTANTS | 2023年 / 36卷 / 06期
关键词
anemia; cytopenia; myelodysplastic syndrome; acute myelogenous leukemia; stem cell transplant; WORLD-HEALTH-ORGANIZATION; MYELOID NEOPLASMS; CLASSIFICATION; REVISION;
D O I
10.1097/01.JAA.0000931428.87936.72
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Myelodysplastic syndromes (MDS) can present as a cytopenia-often as unexplained anemia. Because MDS can progress to acute myelogenous leukemia, primary care providers should be aware of the signs and symptoms, which are associated with the corresponding cytopenia that patients experience and may include fatigue, infection, easy bruising, and bleeding. Treatment options center on managing related cytopenias. The only cure, stem cell transplant, is not readily available.
引用
收藏
页码:17 / 21
页数:5
相关论文
共 22 条
[1]   Myelodysplastic syndromes [J].
Ades, Lionel ;
Itzykson, Raphael ;
Fenaux, Pierre .
LANCET, 2014, 383 (9936) :2239-2252
[2]   Rheumatologic Manifestations in Myelodysplastic Syndrome [J].
Albert, Daniel A. ;
Burns, Christopher M. .
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2012, 18 (03) :148-150
[3]   The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia [J].
Arber, Daniel A. ;
Orazi, Attilio ;
Hasserjian, Robert ;
Thiele, Jurgen ;
Borowitz, Michael J. ;
Le Beau, Michelle M. ;
Bloomfield, Clara D. ;
Cazzola, Mario ;
Vardiman, James W. .
BLOOD, 2016, 127 (20) :2391-2405
[4]   Emerging treatment options for patients with high-risk myelodysplastic syndrome [J].
Bewersdorf, Jan Philipp ;
Carraway, Hetty ;
Prebet, Thomas .
THERAPEUTIC ADVANCES IN HEMATOLOGY, 2020, 11
[5]   Myelodysplastic Syndromes [J].
Cazzola, Mario .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (14) :1358-1374
[6]   The use of genetic tests to diagnose and manage patients with myeloproliferative and myeloproliferative/myelodysplastic neoplasms, and related disorders [J].
Cross, Nicholas C. P. ;
Godfrey, Anna L. ;
Cargo, Catherine ;
Garg, Mamta ;
Mead, Adam J. .
BRITISH JOURNAL OF HAEMATOLOGY, 2021, 195 (03) :338-351
[7]   The immune landscape of myelodysplastic syndromes [J].
Fozza, Claudio ;
Crobu, Valeria ;
Isoni, Maria Antonia ;
Dore, Fausto .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2016, 107 :90-99
[8]   Clinical Practice Guideline for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer: 2010 Update by the Infectious Diseases Society of America [J].
Freifeld, Alison G. ;
Bow, Eric J. ;
Sepkowitz, Kent A. ;
Boeckh, Michael J. ;
Ito, James I. ;
Mullen, Craig A. ;
Raad, Issam I. ;
Rolston, Kenneth V. ;
Young, Jo-Anne H. ;
Wingard, John R. .
CLINICAL INFECTIOUS DISEASES, 2011, 52 (04) :E56-E93
[9]   Revised International Prognostic Scoring System for Myelodysplastic Syndromes [J].
Greenberg, Peter L. ;
Tuechler, Heinz ;
Schanz, Julie ;
Sanz, Guillermo ;
Garcia-Manero, Guillermo ;
Sole, Francesc ;
Bennett, John M. ;
Bowen, David ;
Fenaux, Pierre ;
Dreyfus, Francois ;
Kantarjian, Hagop ;
Kuendgen, Andrea ;
Levis, Alessandro ;
Malcovati, Luca ;
Cazzola, Mario ;
Cermak, Jaroslav ;
Fonatsch, Christa ;
Le Beau, Michelle M. ;
Slovak, Marilyn L. ;
Krieger, Otto ;
Luebbert, Michael ;
Maciejewski, Jaroslaw ;
Magalhaes, Silvia M. M. ;
Miyazaki, Yasushi ;
Pfeilstoecker, Michael ;
Sekeres, Mikkael ;
Sperr, Wolfgang R. ;
Stauder, Reinhard ;
Tauro, Sudhir ;
Valent, Peter ;
Vallespi, Teresa ;
van de Loosdrecht, Arjan A. ;
Germing, Ulrich ;
Haase, Detlef .
BLOOD, 2012, 120 (12) :2454-2465
[10]   Autoimmune manifestations associated with myelodysplastic syndromes [J].
Grignano, Eric ;
Jachiet, Vincent ;
Fenaux, Pierre ;
Ades, Lionel ;
Fain, Olivier ;
Mekinian, Arsene .
ANNALS OF HEMATOLOGY, 2018, 97 (11) :2015-2023