Oral toxicity evaluation of cannabidiol

被引：15

作者：

Henderson, Rayetta G. ^{[1
,5
]}

Lefever, Timothy W. ^{[2
]}

Heintz, Melissa M. ^{[3
]}

Trexler, Kristen R. ^{[2
]}

Borghoff, Susan J. ^{[4
]}

Bonn-Miller, Marcel O. ^{[2
]}

机构：

[1] ToxStrategies Inc, Wilmington, NC 28411 USA

[2] Canopy Growth Corp, Smiths Falls, ON, Canada

[3] ToxStrategies Inc, Asheville, NC 28801 USA

[4] ToxStrategies Inc, Res Triangle Pk, NC 27511 USA

[5] 23501 Cinco Ranch Blvd,Suite B226, Katy, TX 77494 USA

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2023年 / 176卷

关键词：

Cannabidiol; CBD; Hemp; Subchronic toxicity; Rat; Safety; MULTIPLE COMPARISONS; HYPERTROPHY; LESIONS; MODE; RAT;

D O I：

10.1016/j.fct.2023.113778

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Use of cannabidiol (CBD) in humans has increased considerably in recent years. While currently available studies suggest that CBD is relatively safe for human consumption, data from publicly available studies on CBD conducted according to modern testing guidelines are lacking. In the current study, the potential for toxicity following repeated oral exposure to hemp-derived CBD isolate was evaluated in male and female Sprague Dawley rats. No adverse treatment-related effects were observed following administration of CBD via oral gavage for 14 and 90 days at concentrations up to 150 and 140 mg/kg-bw/d, respectively. Microscopic liver and adrenal gland changes observed in the 90-day study were determined to be resolved after a 28-day recovery period. CBD was well tolerated at these dose levels, and the results of this study are comparable to findings reported in unpublished studies conducted with other CBD isolates. The current studies were conducted as part of a broader research program to examine the safety of CBD.

引用

页数：10

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