Exosomes Derived from Endothelial Cells Inhibit Neointimal Hyperplasia Induced by Carotid Artery Injury in Rats via ROS-NLRP3 Inflammasome Pathway

被引：1
作者：
Yang, S. Y. [1 ]
Deng, W. W. [1 ]
Zhao, R. Z. [1 ]
Long, X. P. [1 ]
Wang, D. M. [1 ]
Guo, H. H. [1 ]
Jiang, L. X. [1 ]
Chen, W. M. [1 ]
Shi, B. [1 ]
机构：
[1] Zunyi Med Univ, Dept Cardiol, Affiliated Hosp, Zunyi, Peoples R China
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 174卷 / 06期
关键词：
exosomes; carotid artery injury; vascular repair; inflammation; phenotypic modulation; SMOOTH-MUSCLE-CELLS; IN-STENT RESTENOSIS;
D O I：
10.1007/s10517-023-05788-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
This study attempted to investigate whether exosomes derived from rat endothelial cells (EC-Exo) attenuate intimal hyperplasia after balloon injury using hematoxylin and eosin staining, immunohistochemistry, immunofluorescence staining, Evans blue staining, and Western blotting. The results indicated that EC-Exo inhibited intimal hyperplasia in the carotid artery after balloon injury, promoted re-endothelialization, and reduced vascular inflammation and ROS-NLRP3-mediated cell pyroptosis. Thus, EC-Exo can inhibit neointimal hyperplasia after carotid artery injury in rats presumably by inhibiting the ROS-NLRP3 inflammasome and phenotypic transformation of vascular smooth muscle cells.
引用
收藏
页码：762 / 767
页数：6
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