Tralokinumab treatment for patients with moderate-to-severe atopic dermatitis in daily practice

Tralokinumab was found effective in most patients in this difficult-to-treat, severe atopic dermatitis (AD) daily practice cohort. Interestingly, tralokinumab was also found to be effective in 50% of patients that previously experienced insufficient response or adverse events with dupilumab. Background Evidence about tralokinumab treatment for moderate-to-severe atopic dermatitis (AD) in daily practice is limited. Aim To report the first evidence, to our knowledge, from daily practice of treatment with tralokinumab in patients with AD. Methods In this observational prospective study, patients with AD who received tralokinumab treatment in the context of routine care at the Erasmus Medical Centre were included between November 2021 and February 2022. This included 28 patients who had previously been treated with dupilumab, and 14 patients who had been treated with a Janus kinase inhibitor (JAKi). The Investigator's Global Assessment (IGA; 0-4) and the numeric rating scale peak pruritus during the past 7 days (NRS itch 7d: 0-10), adverse events and reasons for discontinuation were analysed. A good clinical response was defined as any decrease in IGA and NRS itch 7d and if a patient was satisfied with the treatment and wished to continue with therapy. Results In total, 37 patients were treated with tralokinumab. Twenty-two (59%) patients showed a good response to tralokinumab treatment. Fifteen (41%) patients discontinued treatment because of inadequate AD control or adverse events. Treatment-related adverse events were mild in most patients. Half of the patients where treatment with dupilumab had failed had a good clinical response to tralokinumab. Conclusions Tralokinumab was found to be effective in most patients in this cohort with difficult-to-treat, severe AD from daily practice. Interestingly, tralokinumab was also found to be effective in 50% of patients who had previously experienced insufficient response or adverse events with dupilumab treatment.