The Effect of Super-Repressor IkB-Loaded Exosomes (Exo-srIκBs) in Chronic Post-Ischemia Pain (CPIP) Models

被引：7

作者：

Chae, Ji Seon ^{[1
]}

Park, Hyunju ^{[2
]}

Ahn, So-Hee ^{[3
]}

Han, Eun-Chong ^{[3
]}

Lee, Yoonjin ^{[2
]}

Kim, Youn Jin ^{[1
]}

Ahn, Eun-Jin ^{[4
]}

Oh, Hye-Won ^{[1
]}

Lee, Hyun Jung ^{[1
]}

Choi, Chulhee ^{[3
]}

Choi, Youn-Hee ^{[2
]}

Kim, Won-joong ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 07804, South Korea

[2] Ewha Womans Univ, Coll Med, Inflammat Canc Microenvironm Res Ctr, Dept Physiol, Seoul 07804, South Korea

[3] ILIAS Biol Inc, ILIAS Innovat Ctr, Daejeon 34014, South Korea

[4] Chung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul 06974, South Korea

来源：

PHARMACEUTICS | 2023年 / 15卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

exosomes; exosome loaded with super-repressor I kappa B; chronic post-ischemic pain model; complex regional pain syndrome (CRPS); allodynia; NF kappa B; inflammation; neuropathic pain; NEUROPATHIC PAIN; BIS(PHENYLIMIDAZOSELENAZOLYL) DISELENIDE; TRANSCRIPTION FACTOR; T-LYMPHOCYTES; ANIMAL-MODEL; SPINAL-CORD; RAT MODEL; MODULATION; CONTRIBUTES; ACTIVATION;

D O I：

10.3390/pharmaceutics15020553

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Complex regional pain syndrome (CRPS) is a condition associated with neuropathic pain that causes significant impairment of daily activities and functioning. Nuclear factor kappa B (NF kappa B) is thought to play an important role in the mechanism of CRPS. Recently, exosomes loaded with super-repressor inhibitory kappa B (Exo-srI kappa B, I kappa B; inhibitor of NF kappa B) have been shown to have potential anti-inflammatory effects in various inflammatory disease models. We investigated the therapeutic effect of Exo-srI kappa B on a rodent model with chronic post-ischemia pain (CPIP), a representative animal model of Type I CRPS. After intraperitoneal injection of a vehicle, Exo-srI kappa B, and pregabalin, the paw withdrawal threshold (PWT) was evaluated up to 48 h. Administration of Exo-srI kappa B increased PWT compared to the vehicle and pregabalin, and the relative densities of p-I kappa B and I kappa B showed significant changes compared to the vehicle 24 h after Exo-srI kappa B injection. The levels of several cytokines and chemokines were reduced by the administration of Exo-srI kappa B in mice with CPIP. In conclusion, our results showed more specifically the role of NF kappa B in the pathogenesis of CRPS and provided a theoretical background for novel treatment options for CRPS.

引用

页数：16

共 41 条

[1] Mechanisms of disease - Nuclear factor-kappa b - A pivotal transcription factor in chronic inflammatory diseases [J].