Targeting the molecular & cellular pillars of human aging with exercise

被引：41

作者：

Goh, Jorming ^{[1
,2
,3
]}

Wong, Esther ^{[1
,2
,3
]}

Soh, Janjira ^{[3
,4
]}

Maier, Andrea Britta ^{[1
,3
,5
,6
,7
]}

Kennedy, Brian Keith ^{[1
,2
,3
,4
]}

机构：

[1] Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Hlth Longev Translat Res Program, Singapore, Singapore

[2] Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Dept Physiol, Singapore, Singapore

[3] Natl Univ Hlth Syst Nuns, Ctr Hlth Longev, Singapore, Singapore

[4] Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Dept Biochem, Singapore, Singapore

[5] Natl Univ Singapore, Dept Med, Singapore, Singapore

[6] Univ Melbourne, Royal Melbourne Hosp, Dept Med & Aged Care, AgeMelbourne, Parkville, Vic, Australia

[7] Vrije Univ, Dept Human Movement Sci, Amsterdam Movement Sci, AgeAmsterdam, Amsterdam, Netherlands

来源：

FEBS JOURNAL | 2023年 / 290卷 / 03期

关键词：

aging; disruption in proteostasis; dysregulated stress response; epigenetic drift; inflammaging; macromolecular damage; metabolic dysregulation; stem cell exhaustion; MUSCLE MITOCHONDRIAL BIOGENESIS; CIRCULATING ANGIOGENIC CELLS; UNFOLDED PROTEIN RESPONSE; MESSENGER-RNA EXPRESSION; HEMATOPOIETIC STEM-CELLS; CORONARY-HEART-DISEASE; RAT SKELETAL-MUSCLE; VIGOROUS EXERCISE; PHYSICAL-ACTIVITY; DNA-DAMAGE;

D O I：

10.1111/febs.16337

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biological aging is the main driver of age-associated chronic diseases. In 2014, the United States National Institute of Aging (NIA) sponsored a meeting between several investigators in the field of aging biology, who identified seven biological pillars of aging and a consensus review, "Geroscience: Linking Aging to Chronic Disease," was published. The pillars of aging demonstrated the conservation of aging pathways in diverse model organisms and thus represent a useful framework with which to study human aging. In this present review, we revisit the seven pillars of aging from the perspective of exercise and discuss how regular physical exercise can modulate these pillars to stave off age-related chronic diseases and maintain functional capacity.

引用

页码：649 / 668

页数：20

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