Inflammatory biomarkers of frailty: A review

被引：21
作者：
Zhang, Liying [1 ,2 ]
Zeng, Xiaofeng [1 ]
He, Fuqian [1 ]
Huang, Xiaoli [1 ]
机构：
[1] Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, Natl Clin Res Ctr Geriatr, Chengdu, Sichuan, Peoples R China
[2] Gansu Prov Hosp, Dept Gerontol & Geriatr, Lanzhou, Peoples R China
来源：
EXPERIMENTAL GERONTOLOGY | 2023年 / 179卷
关键词：
Frailty; Inflammation; Biomarkers; Geriatric syndrome; Inflammaging; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; OXIDATIVE STRESS; TNF-ALPHA; OLDER-PEOPLE; AGE; ASSOCIATION; MARKERS; SERUM; RISK;
D O I：
10.1016/j.exger.2023.112253
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Frailty is a common geriatric syndrome characterized by increased vulnerability and is associated with adverse clinical events such as falls, hospitalization, and death. Early diagnosis and early intervention can delay or reverse frailty and ensure the healthy aging of older individuals. At present, there are no gold standard biomarkers for the diagnosis of frailty, which mainly relies on the scale to assess frailty, and the scale has shortcomings such as lagging assessment, subjectivity, and poor consistency. Frailty biomarkers help in early diagnosis and intervention in frailty. The purpose of this review is to summarize the existing inflammatory markers of frailty and focus on novel inflammatory biomarkers of frailty that can be used to help identify frailty early and explore potential intervention targets.
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页数：8
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共 118 条
  • [21] Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty
    Ershler, WB
    Keller, ET
    [J]. ANNUAL REVIEW OF MEDICINE, 2000, 51 : 245 - 270
  • [22] A gripping reality: oxidative stress, inflammation, and the pathway to frailty
    Ershler, William B.
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 2007, 103 (01) : 3 - 5
  • [23] A multifactorial intervention for frail older people is more than twice as effective among those who are compliant: complier average causal effect analysis of a randomised trial
    Fairhall, Nicola
    Sherrington, Catherine
    Cameron, Ian D.
    Kurrle, Susan E.
    Lord, Stephen R.
    Lockwood, Keri
    Herbert, Robert D.
    [J]. JOURNAL OF PHYSIOTHERAPY, 2017, 63 (01) : 40 - 44
  • [24] Association of nutritional risk and adverse medical outcomes across different medical inpatient populations
    Felder, Susan
    Lechtenboehmer, Christian
    Bally, Martina
    Fehr, Rebecca
    Deiss, Manuela
    Faessler, Lukas
    Kutz, Alexander
    Steiner, Deborah
    Rast, Anna C.
    Laukemann, Svenja
    Kulkarni, Prasad
    Stanga, Zeno
    Haubitz, Sebastian
    Huber, Andreas
    Mueller, Beat
    Schuetz, Philipp
    [J]. NUTRITION, 2015, 31 (11-12) : 1385 - 1393
  • [25] The value of neutrophil and lymphocyte count in frail older women
    Fernandez-Garrido, Julio
    Navarro-Martinez, Rut
    Buigues-Gonazlez, Cristina
    Martinez-Martinez, Mary
    Ruiz-Ros, Vicente
    Cauli, Omar
    [J]. EXPERIMENTAL GERONTOLOGY, 2014, 54 : 35 - 41
  • [26] The origins of age-related proinflammatory state
    Ferrucci, L
    Corsi, A
    Lauretani, F
    Bandinelli, S
    Bartali, B
    Taub, DD
    Guralnik, JM
    Longo, DL
    [J]. BLOOD, 2005, 105 (06) : 2294 - 2299
  • [27] Franceschi C, 2000, ANN NY ACAD SCI, V908, P244
  • [28] Inflammaging: a new immune-metabolic viewpoint for age-related diseases
    Franceschi, Claudio
    Garagnani, Paolo
    Parini, Paolo
    Giuliani, Cristina
    Santoro, Aurelia
    [J]. NATURE REVIEWS ENDOCRINOLOGY, 2018, 14 (10) : 576 - 590
  • [29] Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
    Franceschi, Claudio
    Campisi, Judith
    [J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2014, 69 : S4 - S9
  • [30] Nonlinear Multisystem Physiological Dysregulation Associated With Frailty in Older Women: Implications for Etiology and Treatment
    Fried, Linda P.
    Xue, Qian-Li
    Cappola, Anne R.
    Ferrucci, Luigi
    Chaves, Paulo
    Varadhan, Ravi
    Guralnik, Jack M.
    Leng, Sean X.
    Semba, Richard D.
    Walston, Jeremy D.
    Blaum, Caroline S.
    Bandeen-Roche, Karen
    [J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2009, 64 (10): : 1049 - 1057
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