Oral and fecal microbiota in patients with diarrheal irritable bowel syndrome

被引：13

作者：

Tang, Binbin ^{[1
,2
]}

Hu, Yunlian ^{[3
,4
]}

Chen, Jianhui ^{[3
,4
]}

Su, Chengxia ^{[3
,4
]}

Zhang, Qian ^{[3
,4
]}

Huang, Chaoqun ^{[3
,4
]}

机构：

[1] Tongde Hosp Zhejiang Prov, Outpatient Dept 2, Hangzhou, Peoples R China

[2] Hubei Univ Chinese Med, Clin Coll Tradit Chinese Med, Wuhan, Peoples R China

[3] Hubei Prov Hosp Tradit Chinese Med, Dept Gastroenterol, Wuhan, Peoples R China

[4] Hubei Univ Chinese Med, Clin Coll 1, Wuhan, Peoples R China

来源：

HELIYON | 2023年 / 9卷 / 01期

关键词：

Fecal microbiota; Oral microbiota; Irritable bowel syndrome; Diarrhea; INFLAMMATION;

D O I：

10.1016/j.heliyon.2023.e13114

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: This study aimed at investigating the characteristics and correlation between oral (tongue coating) and fecal microbiota in patients with diarrheal irritable bowel syndrome (IBS-D).Methods: Fifty-two IBS-D patients were chosen, with ten healthy volunteers serving as the normal control group. Tongue coating samples and fecal samples of subjects were sequenced for the 16S rRNA gene (V4-V5). Bioinformatics analysis was done on the test data to investigate oral and fecal microbiota composition characteristics in IBS-D patients.Results: The microbial richness of tongue coating in IBS-D group was lower than that in the normal control group (P < 0.05). The beta diversity of tongue coating microbiota and fecal microbiota was significantly different in the IBS-D group compared to the normal control group (P < 0.05). Pseudomonadales (Pseudomonadaceae and Pseudomonas), Moraxellaceae, Parvimonas, Peptos-treptococcus, and Alloprevotella were considerably high in number the tongue coating samples of the IBS-D group in comparison to the normal control group. Similarly, the fecal samples from the IBS-D group were significantly enriched in Alphaproteobacteria, Pseudomonadales (Pseudomona-daceae and Pseudomonas), Acidaminococcaceae, Phascolarctobacterium, Alloprevotella, and Escher-ichia compared to the normal control group.Conclusions: The oral and fecal microbiotas of IBS-D patients differ from those of the control group; hence studying IBS-D from the perspective of the oral-gut microbiome axis is an interesting research avenue.

引用

页数：10