Calcium Homeostasis, Transporters, and Blockers in Health and Diseases of the Cardiovascular System

被引：25
作者：
Bkaily, Ghassan [1 ]
Jacques, Danielle [1 ]
机构：
[1] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Immunol & Cell Biol, Sherbrooke, PQ J1H 5N4, Canada
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 10期
基金：
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词：
calcium; calcium homeostasis; calcium overload; hypercalcemia; Cav1; Cav2; Cav3; L-type calcium channel; P/Q-type calcium channel; N-type calcium channel; R-type calcium channel; T-type calcium channel; calcium channel blockers; G protein; GPCR; calcium pumps; sodium; calcium exchanger; endoplasmic reticulum; nucleus; mitochondria; NA+-H+ EXCHANGER; SMOOTH-MUSCLE; PROTEIN-KINASE; SARCOPLASMIC-RETICULUM; NA+/CA2+ EXCHANGER; CA2+ CHANNEL; RYANODINE RECEPTOR; NA+-CA2+ EXCHANGER; CATION CHANNEL; HEART-CELLS;
D O I：
10.3390/ijms24108803
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Calcium is a highly positively charged ionic species. It regulates all cell types' functions and is an important second messenger that controls and triggers several mechanisms, including membrane stabilization, permeability, contraction, secretion, mitosis, intercellular communications, and in the activation of kinases and gene expression. Therefore, controlling calcium transport and its intracellular homeostasis in physiology leads to the healthy functioning of the biological system. However, abnormal extracellular and intracellular calcium homeostasis leads to cardiovascular, skeletal, immune, secretory diseases, and cancer. Therefore, the pharmacological control of calcium influx directly via calcium channels and exchangers and its outflow via calcium pumps and uptake by the ER/SR are crucial in treating calcium transport remodeling in pathology. Here, we mainly focused on selective calcium transporters and blockers in the cardiovascular system.
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页数：25
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