Calcium Homeostasis, Transporters, and Blockers in Health and Diseases of the Cardiovascular System

被引：19
作者：
Bkaily, Ghassan [1 ]
Jacques, Danielle [1 ]
机构：
[1] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Immunol & Cell Biol, Sherbrooke, PQ J1H 5N4, Canada
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 10期
基金：
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词：
calcium; calcium homeostasis; calcium overload; hypercalcemia; Cav1; Cav2; Cav3; L-type calcium channel; P/Q-type calcium channel; N-type calcium channel; R-type calcium channel; T-type calcium channel; calcium channel blockers; G protein; GPCR; calcium pumps; sodium; calcium exchanger; endoplasmic reticulum; nucleus; mitochondria; NA+-H+ EXCHANGER; SMOOTH-MUSCLE; PROTEIN-KINASE; SARCOPLASMIC-RETICULUM; NA+/CA2+ EXCHANGER; CA2+ CHANNEL; RYANODINE RECEPTOR; NA+-CA2+ EXCHANGER; CATION CHANNEL; HEART-CELLS;
D O I：
10.3390/ijms24108803
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Calcium is a highly positively charged ionic species. It regulates all cell types' functions and is an important second messenger that controls and triggers several mechanisms, including membrane stabilization, permeability, contraction, secretion, mitosis, intercellular communications, and in the activation of kinases and gene expression. Therefore, controlling calcium transport and its intracellular homeostasis in physiology leads to the healthy functioning of the biological system. However, abnormal extracellular and intracellular calcium homeostasis leads to cardiovascular, skeletal, immune, secretory diseases, and cancer. Therefore, the pharmacological control of calcium influx directly via calcium channels and exchangers and its outflow via calcium pumps and uptake by the ER/SR are crucial in treating calcium transport remodeling in pathology. Here, we mainly focused on selective calcium transporters and blockers in the cardiovascular system.
引用
收藏
页数：25
相关论文
共 259 条
  • [1] Custom distinctions in the interaction of G-protein β subunits with N-type (CaV2.2) versus P/Q-type (CaV2.1) calcium channels
    Agler, HL
    Evans, J
    Colecraft, HM
    Yue, DT
    [J]. JOURNAL OF GENERAL PHYSIOLOGY, 2003, 121 (06) : 495 - 510
  • [2] Akk G., 2008, V182, P53, DOI 10.1007/978-3-540-74806-9_3
  • [3] Calcium Channel Blocker Toxicity: A Practical Approach
    Alshaya, Omar A.
    Alhamed, Arwa
    Althewaibi, Sara
    Fetyani, Lolwa
    Alshehri, Shaden
    Alnashmi, Fai
    Alharbi, Shmeylan
    Alrashed, Mohammed
    Alqifari, Saleh F.
    Alshaya, Abdulrahman, I
    [J]. JOURNAL OF MULTIDISCIPLINARY HEALTHCARE, 2022, 15 : 1851 - 1862
  • [4] Targeting N-type calcium channels in young-onset of some neurological diseases
    Antunes, Flavia Tasmin Techera
    De Souza, Alessandra Hubner
    Figueira, Juliana
    Binda, Nancy Scardua
    Carvalho, Vanice Paula Ricardo
    Vieira, Luciene Bruno
    Gomez, Marcus Vinicius
    [J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
  • [5] Organic cation permeation through the channel formed by polycystin-2
    Anyatonwu, GI
    Ehrlich, BE
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (33) : 29488 - 29493
  • [6] Mitochondrial membrane potential instability on reperfusion after ischemia does not depend on mitochondrial Ca2+ uptake
    Ashok D.
    Papanicolaou K.
    Sidor A.
    Wang M.
    Solhjoo S.
    Liu T.
    O'Rourke B.
    [J]. Journal of Biological Chemistry, 2023, 299 (06)
  • [7] Presence of tubular and reticular structures in the nucleus of human vascular smooth muscle cells
    Avedanian, Levon
    Jacques, Danielle
    Bkaily, Ghassan
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2011, 50 (01) : 175 - 186
  • [8] Hypertension: sex-related differences in drug treatment, prevalence and blood pressure control in primary care
    Bager, Johan-Emil
    Manhem, Karin
    Andersson, Tobias
    Hjerpe, Per
    Bengtsson-Bostrom, Kristina
    Ljungman, Charlotta
    Mourtzinis, Georgios
    [J]. JOURNAL OF HUMAN HYPERTENSION, 2023, 37 (08) : 662 - 670
  • [9] ION CHANNELS The voltage-sensor quartet
    Bankston, J. R.
    Kass, R. S.
    [J]. NATURE, 2008, 456 (7219) : 183 - 185
  • [10] Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic
    Batiste, Suzanne M.
    Blackwell, Daniel J.
    Kim, Kyungsoo
    Kryshtal, Dmytro O.
    Gomez-Hurtado, Nieves
    Rebbeck, Robyn T.
    Cornea, Razvan L.
    Johnston, Jeffrey N.
    Knollmann, Bjorn C.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (11) : 4810 - 4815
12345678910