Calcium Homeostasis, Transporters, and Blockers in Health and Diseases of the Cardiovascular System

被引：25

作者：

Bkaily, Ghassan ^{[1
]}

Jacques, Danielle ^{[1
]}

机构：

[1] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Immunol & Cell Biol, Sherbrooke, PQ J1H 5N4, Canada

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 10期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

calcium; calcium homeostasis; calcium overload; hypercalcemia; Cav1; Cav2; Cav3; L-type calcium channel; P/Q-type calcium channel; N-type calcium channel; R-type calcium channel; T-type calcium channel; calcium channel blockers; G protein; GPCR; calcium pumps; sodium; calcium exchanger; endoplasmic reticulum; nucleus; mitochondria; NA+-H+ EXCHANGER; SMOOTH-MUSCLE; PROTEIN-KINASE; SARCOPLASMIC-RETICULUM; NA+/CA2+ EXCHANGER; CA2+ CHANNEL; RYANODINE RECEPTOR; NA+-CA2+ EXCHANGER; CATION CHANNEL; HEART-CELLS;

D O I：

10.3390/ijms24108803

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium is a highly positively charged ionic species. It regulates all cell types' functions and is an important second messenger that controls and triggers several mechanisms, including membrane stabilization, permeability, contraction, secretion, mitosis, intercellular communications, and in the activation of kinases and gene expression. Therefore, controlling calcium transport and its intracellular homeostasis in physiology leads to the healthy functioning of the biological system. However, abnormal extracellular and intracellular calcium homeostasis leads to cardiovascular, skeletal, immune, secretory diseases, and cancer. Therefore, the pharmacological control of calcium influx directly via calcium channels and exchangers and its outflow via calcium pumps and uptake by the ER/SR are crucial in treating calcium transport remodeling in pathology. Here, we mainly focused on selective calcium transporters and blockers in the cardiovascular system.

引用

页数：25

共 259 条

[1] Custom distinctions in the interaction of G-protein β subunits with N-type (CaV2.2) versus P/Q-type (CaV2.1) calcium channels [J].

Agler, HL ;

Evans, J ;

Colecraft, HM ;

Yue, DT .

JOURNAL OF GENERAL PHYSIOLOGY, 2003, 121 (06) :495-510

[2]

Akk G., 2008, V182, P53, DOI 10.1007/978-3-540-74806-9_3

[3] Calcium Channel Blocker Toxicity: A Practical Approach [J].

Alshaya, Omar A. ;

Alhamed, Arwa ;

Althewaibi, Sara ;

Fetyani, Lolwa ;

Alshehri, Shaden ;

Alnashmi, Fai ;

Alharbi, Shmeylan ;

Alrashed, Mohammed ;

Alqifari, Saleh F. ;

Alshaya, Abdulrahman, I .

JOURNAL OF MULTIDISCIPLINARY HEALTHCARE, 2022, 15 :1851-1862

[4] Targeting N-type calcium channels in young-onset of some neurological diseases [J].

Antunes, Flavia Tasmin Techera ;

De Souza, Alessandra Hubner ;

Figueira, Juliana ;

Binda, Nancy Scardua ;

Carvalho, Vanice Paula Ricardo ;

Vieira, Luciene Bruno ;

Gomez, Marcus Vinicius .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10

[5] Organic cation permeation through the channel formed by polycystin-2 [J].

Anyatonwu, GI ;

Ehrlich, BE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (33) :29488-29493

[6] Mitochondrial membrane potential instability on reperfusion after ischemia does not depend on mitochondrial Ca2+uptake [J].

Ashok, Deepthi ;

Papanicolaou, Kyriakos ;

Sidor, Agnieszka ;

Wang, Michelle ;

Solhjoo, Soroosh ;

Liu, Ting ;

O'Rourke, Brian .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 299 (06)

[7] Presence of tubular and reticular structures in the nucleus of human vascular smooth muscle cells [J].

Avedanian, Levon ;

Jacques, Danielle ;

Bkaily, Ghassan .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2011, 50 (01) :175-186

[8] Hypertension: sex-related differences in drug treatment, prevalence and blood pressure control in primary care [J].

Bager, Johan-Emil ;

Manhem, Karin ;

Andersson, Tobias ;

Hjerpe, Per ;

Bengtsson-Bostrom, Kristina ;

Ljungman, Charlotta ;

Mourtzinis, Georgios .

JOURNAL OF HUMAN HYPERTENSION, 2023, 37 (08) :662-670

[9] ION CHANNELS The voltage-sensor quartet [J].

Bankston, J. R. ;

Kass, R. S. .

NATURE, 2008, 456 (7219) :183-185

[10] Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic [J].

Batiste, Suzanne M. ;

Blackwell, Daniel J. ;

Kim, Kyungsoo ;

Kryshtal, Dmytro O. ;

Gomez-Hurtado, Nieves ;

Rebbeck, Robyn T. ;

Cornea, Razvan L. ;

Johnston, Jeffrey N. ;

Knollmann, Bjorn C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (11) :4810-4815

← 1 2 3 4 5 6 7 8 9 10 →