Identification of shared fatty acid metabolism related signatures in dilated cardiomyopathy and myocardial infarction

被引:1
作者
Huang, Baoyi [1 ]
Lin, Hanying [2 ]
Zhang, Qingfang [3 ]
Luo, Yujun [4 ]
Zhou, Biyao [5 ]
Zhuo, Zewei [3 ]
Sha, Weihong [3 ]
Wei, Jiahui [1 ]
Luo, Lihua [1 ]
Zhang, Huajuan [3 ]
Chen, Kequan [6 ]
机构
[1] Guangzhou Med Univ, Guangzhou 511436, Peoples R China
[2] First Peoples Hosp Zhaoqing, Dept Endocrinol, Zhaoqing 526020, Peoples R China
[3] Southern Med Univ, Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Gastroenterol, Guangzhou 510080, Peoples R China
[4] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Gastroenterol, Guangzhou 510630, Peoples R China
[5] Southern Med Univ, Stomatol Hosp, Dept Periodont, Guangzhou 510280, Peoples R China
[6] Guangzhou Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou 510120, Peoples R China
来源
FUTURE SCIENCE OA | 2023年 / 9卷 / 03期
基金
中国国家自然科学基金;
关键词
dilated cardiomyopathy; fatty acid metabolism; immune infiltration; myocardial infarction; nomogram; risk prediction; LONG NONCODING RNA; MAST-CELLS; DYSFUNCTION; ACTIVATION; MORTALITY; SEVERITY; FIBROSIS; DISEASE; RATIO;
D O I
10.2144/fsoa-2023-0008
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Aim: It is to be elucidated the risk-predictive role of differentially expressed fatty acid metabolism related genes (DE-FRGs) in dilated cardiomyopathy (DCM) and myocardial infarction. Materials & methods: Four gene enrichment analyses defined DE-FRGs' biological functions and pathways. Three strategies were applied to identify risk biomarkers and construct a nomogram. The 4-DE-FRG correlation with immune cell infiltration, drugs, and ceRNA was explored. Results: DE-FRGs were enriched in lipid metabolism. A risk nomogram was established by ACSL1, ALDH2, CYP27A1 and PPARA, demonstrating a good ability for DCM and myocardial infarction prediction. PPARA was positively correlated with adaptive immunocytes. Thirty-five drugs are candidate therapeutic targets. Conclusion: A nomogram and new biological targets for early diagnosis and treatment of DCM and myocardial infarction were provided. Plain language summaryDilated cardiomyopathy (DCM) and myocardial infarction (MI) are two common types of heart disease. This study investigated the fatty acid metabolism related genes to predict the risk of DCM or MI. Four of them (ACSL1, ALDH2, CYP27A1 and PPARA) were effective in predicting disease risk. Additionally, PPARA was found to be associated with immune cell infiltration, and 35 drugs emerged as potential therapeutic targets for these diseases. This study may provide insights into the early diagnosis and treatment of DCM and MI.
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页数:19
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