The association between genital mycoplasma infection and spontaneous abortion: A systematic review and meta-analysis

被引：3
作者：
Chen, Wei [1 ]
Xiong, Shimin [1 ]
Shen, Xubo [1 ]
Qiu, Ting [1 ]
He, Caidie [1 ]
An, Songlin [1 ]
Zhou, Yuanzhong [1 ]
机构：
[1] Zunyi Med Univ, Sch Publ Hlth, Zunyi, Peoples R China
来源：
REPRODUCTIVE TOXICOLOGY | 2023年 / 116卷
基金：
国家重点研发计划;
关键词：
Meta; -analysis; Mycoplasma infection; Pregnancy; Spontaneous abortion; UREAPLASMA-UREALYTICUM; ENDOCERVICAL INFECTION; ADVERSE OUTCOMES; PREVALENCE; PRETERM; HOMINIS; DIAGNOSTICS; PREGNANCY; AGENT; WOMEN;
D O I：
10.1016/j.reprotox.2023.108334
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Epidemiological findings on the association between genital mycoplasma infection (GMI) and spontaneous abortion are inconsistent. Therefore, this meta-analysis aims to determine whether mycoplasma infection during pregnancy increases the risk of spontaneous abortion. An electronic database search was conducted using China National Knowledge Infrastructure, Elsevier, PubMed, SinoMed, The Cochrane Library, and Wanfang Database from database establishment to October 2021. Sixteen case-controls and 3 prospective cohorts were included. The meta-analysis showed that GMI was positively associated with spontaneous abortion (odds ratio (OR) 2.35, 95% confidence interval (CI) 1.50, 3.67). Of them, case-control studies showed that the GMI proportion in the spontaneous abortion group was higher than that in the normal group (OR 2.13, 95% CI 1.33, 3.43); the cohort study showed that the spontaneous abortion rate in the GMI group was higher than those in non-infected groups (relative risk 5.17, 95% CI 2.07, 12.95; risk difference 0.18, 95% CI 0.09, 0.27). Each outcome indicator was relatively robust in the sensitivity analysis, and no significant publication bias was found in the funnel plots. Our data support that GMI during pregnancy increases the risk of spontaneous abortion. Thus, the monitoring and timely treatment of GMI before pregnancy of GMI are essential to decrease the risk of spontaneous abortion.
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页数：9
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共 70 条
[51]   Human miscarriage and infection in Tunisia: Role of Mycoplasma hominis and high Waddlia seroprevalence [J].
Smaoui, Mariem ;
Carole, Kebbi ;
Sellami, Hanen ;
Kammoun, Salma ;
Choura, Khaled ;
Maazoun, Leila ;
Mestiri, Houssem ;
Aeby, Sebastien ;
Louati, Doulira ;
Derbel, Mohamed ;
Chaabene, Kais ;
Hammami, Adnene ;
Greub, Gilbert ;
Znazen, Abir .
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2019, 13 (05) :410-418
[52]   Placental Infection With Ureaplasma species Is Associated With Histologic Chorioamnionitis and Adverse Outcomes in Moderately Preterm and Late-Preterm Infants [J].
Sweeney, Emma L. ;
Kallapur, Suhas G. ;
Gisslen, Tate ;
Lambers, Donna S. ;
Chougnet, Claire A. ;
Stephenson, Sally-Anne ;
Jobe, Alan H. ;
Knox, Christine L. .
JOURNAL OF INFECTIOUS DISEASES, 2016, 213 (08) :1340-1347
[53]   The haplotypes GCA and ACA in ESR1 gene are associated with the susceptibility of recurrent spontaneous abortion (RSA) in Chinese Han A case-control study and meta-analysis [J].
Tang, Liang ;
Xiang, Qin ;
Xiang, Ju ;
Li, Jianming .
MEDICINE, 2022, 101 (21) :E29168
[54]  
Tao J., 2011, J HUBEI MED COLL, V30, P85
[55]   Mycoplasma genitalium: from Chrysalis to Multicolored Butterfly [J].
Taylor-Robinson, David ;
Jensen, Jorgen Skov .
CLINICAL MICROBIOLOGY REVIEWS, 2011, 24 (03) :498-514
[56]  
Wanbao X., 2015, INT J LAB MED, P3357, DOI [10.3969/j.issn.1673-4130.2015.22.066, DOI 10.3969/J.ISSN.1673-4130.2015.22.066]
[57]   Abnormalities in spontaneous abortions detected by G-banding and chromosomal microarray analysis (CMA) at a national reference laboratory [J].
Wang, Boris T. ;
Chong, Thomas P. ;
Boyar, Fatih Z. ;
Kopita, Kimberly A. ;
Ross, Leslie P. ;
El-Naggar, Mohamed M. ;
Sahoo, Trilochan ;
Wang, Jia-Chi ;
Hemmat, Morteza ;
Haddadin, Mary H. ;
Owen, Renius ;
Anguiano, Arturo L. .
MOLECULAR CYTOGENETICS, 2014, 7
[58]  
Wang L.J., 2018, MOD DIAGN TREAT, V29, DOI [10.3969/j.issn.1001-8174.2018.19.042, DOI 10.3969/J.ISSN.1001-8174.2018.19.042]
[59]  
Wu H R., 2006, Chinese Journal of School Health, V27, P18, DOI [10.3969/j.issn.1000-9817.2006.01.017, DOI 10.3969/J.ISSN.1000-9817.2006.01.017]
[60]   Molecular cytogenetic analysis of early spontaneous abortions conceived from varying assisted reproductive technology procedures [J].
Wu, Tonghua ;
Yin, Biao ;
Zhu, Yuanchang ;
Li, Guangui ;
Ye, Lijun ;
Chen, Chunmei ;
Zeng, Yong ;
Liang, Desheng .
MOLECULAR CYTOGENETICS, 2016, 9 :1-6
1234567