Core-Shell Fe3O4@C Nanoparticles as Highly Effective T2 Magnetic Resonance Imaging Contrast Agents: In Vitro and In Vivo Studies

被引：9

作者：

Yue, Huan ^{[1
,6
]}

Zhao, Dejun ^{[1
]}

Tegafaw, Tirusew ^{[1
]}

Ahmad, Mohammad Yaseen ^{[1
]}

Saidi, Abdullah Khamis Ali Al ^{[1
]}

Liu, Ying ^{[1
]}

Cha, Hyunsil ^{[2
]}

Yang, Byeong Woo ^{[3
]}

Chae, Kwon Seok ^{[4
]}

Nam, Sung-Wook ^{[5
]}

Chang, Yongmin ^{[5
]}

Lee, Gang Ho ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Nat Sci, Dept Chem, Taegu 41566, South Korea

[2] Kyungpook Natl Univ, Sch Med, Div Biomed Sci, Taegu 41944, South Korea

[3] Theranocure, Medlifesci Bldg 1, Taegu 41405, South Korea

[4] Kyungpook Natl Univ, Teachers Coll, Dept Biol Educ, Taegu 41566, South Korea

[5] Kyungpook Natl Univ, Sch Med, Dept Mol Med, Taegu 41944, South Korea

[6] Pingdingshan Univ, Sch Chem & Environm Engn, Pingdingshan 467000, Peoples R China

来源：

NANOMATERIALS | 2024年 / 14卷 / 02期

关键词：

Fe3O4@C nanoparticle; core shell; magnetic resonance imaging; contrast agent; highly effective; AMORPHOUS-CARBON;

D O I：

10.3390/nano14020177

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnetite nanoparticles (Fe3O4 NPs) have been intensively investigated because of their potential biomedical applications due to their high saturation magnetization. In this study, core-shell Fe3O4@C NPs (core = Fe3O4 NPs and shell = amorphous carbons, d(avg) = 35.1 nm) were synthesized in an aqueous solution. Carbon coating terminated with hydrophilic -OH and -COOH groups imparted excellent biocompatibility and hydrophilicity to the NPs, making them suitable for biomedical applications. The Fe3O4@C NPs exhibited ideal relaxometric properties for T-2 magnetic resonance imaging (MRI) contrast agents (i.e., high transverse and negligible longitudinal water proton spin relaxivities), making them exclusively induce only T-2 relaxation. Their T-2 MRI performance as contrast agents was confirmed in vivo by measuring T-2 MR images in mice before and after intravenous injection.

引用

页数：12

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